David Rocco (Bergmeier lab) Elucidating a novel pathway for platelet activation Understanding how this pathway contributes to platelet adhesion under arterial shear stress Andrew Kennedy (Thaxton lab) ER sheet dynamics are distended in T cells in solid cancers Balancing ER sheets and tubules may protect T cells from disturbed ER dynamics in solid tumors
Kimberly Lukasik (Gupton lab) TRIM9 modulates focal adhesion dynamics to regulate cell motility in melanoma Emily Bulik-Sullivan (Randell lab) Elucidating the mechanism of ENaC activity reduction by CC-90009 This mechanism, and CC-90009’s capacity to promote ribosomal readthrough of PTC-CFTR variants is of therapeutic interest for cystic fibrosis
Gabby Bais (Giudice lab) FXR1 may regulate the translation of many cardiomyocyte-specific proteins Expression of muscle-specific splice isoforms of FXR1 may impact the contractility of the adult heart Sherry Hsu (Cohen lab) Tubulin acetylation and polyglutamylation increase early in neuronal differentiation, exhibit distinct distributions, and are important for maintaining neuronal morphology Tubulin acetylation … Read more
Henry Uchenna (Maddox lab) Capping Protein depletion accelerates furrowing and cytokinesis, likely due to increased F-actin in the contractile ring It also disrupts spindle dynamics, potentially through effects on the dynein-dynactin complex Meghan Anderman (McCauley lab) Using human intestinal organoids to model gastrointestinal (GI) pathophysiology in cystic fibrosis Assessing the general role of … Read more
Leo Bondel (Zylka lab) Our goal is to identify guide RNAs targeting the UBE3A-ATS in human neurons, which allow for installation of a Poly(A) signal with cytosine base editors These edits have the potential to restore UBE3A expression, making this an attractive therapeutic strategy for Angelman Syndrome Katie Holmes (Baldwin lab) White matter astrocytes maintain … Read more
Jack Bennett (Cook lab) Intracellular pH can be manipulated by inhibiting ion transporters, and these changes can be measured by flow cytometry pH manipulations may alter cell cycle progression, arresting cells in the G1 phase of the cell cycle Lauren Griffith (Williams lab) Explore how integrin-β1 and its adaptor protein Talin loss-of function … Read more
Michelle LaBella (Yeh lab) TNIK is required to restrain tumor invasion in PDAC Clear difference in mechanism when compared to colorectal/lung cancer TNIK is a newly identified regulator of PLAT, tPA expression and ECM modulation through fibrin degradation New mechanism for PDAC invasion and metastasis, may be what restrains classical tumors Mady Chlebowski … Read more
Anna Beeson (Caron lab) Adrenomedullin robustly increases both mouse fertility and pinopode formation Alternative model systems are allowing us to interrogate pinopode formation in novel ways Vickie Williams (Cohen lab) Dimerization fluorescent proteins are a useful tool that can show increased ER-LD contacts under conditions of lipid droplet biogenesis Dimerization-dependent fluorescent proteins can … Read more
Keith Breau (Magness and Elston labs) Using a reaction-diffusion model to simulate planar cell polarity in an epithelial cell layer Demonstrating a role for planar cell polarity in regulating intestinal epithelial migration Pierre N’Guetta (O'Brien lab) Total renal denervation in mice leads to a decrease in number of nephron developed Denervated kidneys exhibit … Read more
Max Hockenberry (Bear and Legant labs) We have developed an imaging based approach to directly visualize the motion of single molecules of actin and the arp2/3 complex in living cells. We have used this approach and preliminary data to assess how molecules of these proteins get to the front of the cell for incorporation in … Read more
