Samir Parikh, MD Ruth W. and Milton P. Levy, Sr. Chair in Molecular Nephrology Robert Tucker Hayes Distinguished Chair in Nephrology Professor & Chief of the Division of Nephrology, Dept. of Internal Medicine University of Texas Southwestern Medical Center Research focus Turning back kidney frailty by targeting metabolism Faculty host Lori O'Brien, PhD More … Read more
Danielle Schmitt PhD Assistant Professor, Department of Chemistry and Biochemistry University of California, Los Angeles Research focus Illuminating compartmentalized metabolic regulation in single cells Faculty host Whitney Edwards, PhD More information on speaker Danielle Schmitt obtained her Bachelor of Science in chemistry and biochemistry from Ball State University, where she was a Lewis Stokes … Read more
Matt Zimmerman (Miller lab) FRb inhibits macrophage survival and suppresses anti-tumor functions in vitro FRb ablation decreases tumor growth in preliminary experiments Nicole Hondrogiannis (Deshmukh lab) Neurons are long-lived post mitotic cells Exploring if the apoptotic pathway in neurons becomes activated in response to sublethal DNA damage
Juliet King (Williams lab) Alex Powers (Cohen lab)
Ian McCabe (Yeh lab) Identifying two clinically relevant populations of CAFs in PDAC: tumor promoting (proCAF) and tumor restrictive (restCAF) These CAF subtypes are distributed spatially and may play distinct functional roles Mark Hazelbaker (Bear lab) The Arp2/3 complex is required for the turnover of clathrin plaques ACK regulates the recruitment of the Arp2/3 complex … Read more
David Rocco (Bergmeier lab) Elucidating a novel pathway for platelet activation Understanding how this pathway contributes to platelet adhesion under arterial shear stress Andrew Kennedy (Thaxton lab) ER sheet dynamics are distended in T cells in solid cancers Balancing ER sheets and tubules may protect T cells from disturbed ER dynamics in solid tumors
Kimberly Lukasik (Gupton lab) TRIM9 modulates focal adhesion dynamics to regulate cell motility in melanoma Emily Bulik-Sullivan (Randell lab) Elucidating the mechanism of ENaC activity reduction by CC-90009 This mechanism, and CC-90009’s capacity to promote ribosomal readthrough of PTC-CFTR variants is of therapeutic interest for cystic fibrosis
Gabby Bais (Giudice lab) FXR1 may regulate the translation of many cardiomyocyte-specific proteins Expression of muscle-specific splice isoforms of FXR1 may impact the contractility of the adult heart Sherry Hsu (Cohen lab) Tubulin acetylation and polyglutamylation increase early in neuronal differentiation, exhibit distinct distributions, and are important for maintaining neuronal morphology Tubulin acetylation … Read more
Henry Uchenna (Maddox lab) Capping Protein depletion accelerates furrowing and cytokinesis, likely due to increased F-actin in the contractile ring It also disrupts spindle dynamics, potentially through effects on the dynein-dynactin complex Meghan Anderman (McCauley lab) Using human intestinal organoids to model gastrointestinal (GI) pathophysiology in cystic fibrosis Assessing the general role of … Read more
Leo Bondel (Zylka lab) Our goal is to identify guide RNAs targeting the UBE3A-ATS in human neurons, which allow for installation of a Poly(A) signal with cytosine base editors These edits have the potential to restore UBE3A expression, making this an attractive therapeutic strategy for Angelman Syndrome Katie Holmes (Baldwin lab) White matter astrocytes maintain … Read more
