December 2011 – Collaborators Ben Philpot, Mark Zylka and Bryan Roth identify compounds that cause the dormant Ube3a gene to be expressed.

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At top, a mouse brain showing flourescent expression of the UBE3A gene, and below, lack of expression when the maternal copy of the gene is missing.

December 2011 – An interdisciplinary team of UNC scientists say they have found a way to “awaken” the paternal allele of Ube3a, which could lead to a potential treatment strategy for Angelman syndrome (AS). Their results were published online by the journal Nature. Read the complete UNC School of Medicine news release >>

Simons Foundation Autism Research Institute news release >>