There is an urgent need for a vaccine with efficacy against SARS-CoV-2. We hypothesize that peptide vaccines containing epitope regions optimized for concurrent B cell, CD4+ T cell, and CD8+ T cell stimulation would drive both humoral and cellular immunity with high specificity, potentially avoiding undesired effects such as antibody-dependent enhancement (ADE)

Christoph Rau, PhD My research focuses on using model organism populations to study cardiovascular disease.  I obtained my PhD in Microbiology, Immunology and Molecular Genetics at UCLA, where I began working with the Hybrid Mouse Diversity Panel to study the genetics underlying heart failure.  In my postdoc, I expanded into studying the epigenome and developing … Continued

A multidisciplinary team led by Dr. Mark Zylka shows that deletion of TOP1, an enzyme that relieves DNA stress during transcription, in neurons causes genomic instability and early onset of neurodegeneration. Read this exciting work in Nature  

Researchers led by Blossom Damania, PhD, reported that Kaposi sarcoma-associated herpesvirus, a virus linked to three human cancers, uses a protein produced by its human host to come out of hiding and reactivate.

Jonathan Serody, MD, director of UNC’s Bone Marrow Transplantation & Cellular Therapy Program, is the new division chief for hematology. Ethan Basch, MD, the Richard M. Goldberg Distinguished Professor in Medical Oncology, is the new division chief for oncology. Both are members of the UNC Lineberger Comprehensive Cancer Center. More

Christoph Rau, PhD My research focuses on using model organism populations to study cardiovascular disease.  I obtained my PhD in Microbiology, Immunology and Molecular Genetics at UCLA, where I began working with the Hybrid Mouse Diversity Panel to study the genetics underlying heart failure.  In my postdoc, I expanded into studying the epigenome and developing … Continued

I have joined the faculty of the Department of Pharmacology and Computational Medicine Program at UNC Chapel Hill. Previously I was a postdoctoral fellow with Peter K. Sorger at Harvard Medical School’s Laboratory of Systems Pharmacology and Department of Systems Biology, where I applied experiments and computation to understand the mechanisms of combinations of cancer … Continued

December 19, 2019 Lisa A. Carey, MD, FASCO The American Society of Clinical Oncology has elected UNC Lineberger Comprehensive Cancer Center’s Lisa A. Carey, MD, FASCO, to its Board of Directors. She will begin her four-year term during ASCO’s annual meeting in June 2020.

With many thanks to the many great PIs affiliated with these papers published in Nature 06 February 2020 issue, we would like to honorable mention the PIs from UNC Computational Medicine Program: Charles Perou, PhD, Katherine Hoadley, PhD and Joel Parker, PhD  Read Article Here

Dr. Katherine Hoadley is an Assistant Professor in the Department of Genetics and the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill.  Her research interests include integrative genomic analyses to better understand cancer. She has been a member of the Cancer Genome Atlas (TCGA) Project for over a decade. She was … Continued