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Can scientists predict which cancer markers are likely to trigger an immune response?

September 27, 2019
UNC Lineberger’s Benjamin G. Vincent, MD, and Christof Smith, PhD.   Scientists at the University of North Carolina Lineberger Comprehensive Cancer Center have designed and validated a model for predicting what might make an effective cancer vaccine against a patient’s tumor. This finding could help overcome a significant obstacle in...

UNC School of Medicine’s Wesley Legant named Beckman Young Investigator

September 5, 2019
June 14, 2019 Wesley Legant, PhD, assistant professor in the departments of Pharmacology and Biomedical Engineering, earned this prestigious early career award for his work developing new fluorescence microscopes for rapid three-dimensional imaging. Wesley Legant, PhD, assistant professor in the Department of Pharmacology and the UNC/NCSU Joint Department of Biomedical...

Charles M. Perou, PhD: From studying one gene, to studying thousands in breast cancer

August 29, 2019
August 7, 2019 Charles M. Perou, PhD Before he set out to understand how tens of thousands of genes are behaving in breast cancer, Charles M. Perou, PhD, was hunting just one gene. As a graduate student at the University of Utah in the 1990s, Perou was focused on finding...

2019 Hettleman Prizes awarded to promising early-career faculty

August 26, 2019
2019 Hettleman Prizes awarded to promising early-career faculty August 22, 2019 – 2:37 pm | Posted in A-Migrate, Arts & Humanities, Research, Science & Technology The annual Phillip and Ruth Hettleman Prizes for Artistic and Scholarly Achievement have been awarded to four associate professors who exemplify groundbreaking and innovative research along...

Scientists Make Single-cell Map to Reprogram Scar Tissue into Healthy Heart Cells

June 20, 2019
UNC McAllister Heart Institute scientists led by Li Qian, PhD, developed a single-cell genomics pipeline to discover the molecular roadmap underlying the conversion of human scar-making fibroblasts into cardiomyocytes.

Vincent Lab discovers six immune subtypes of cancer

April 8, 2019
Benjamin Vincent, MD, Assistant Professor in the School of Medicine (Hematology/Oncology) and his lab have performed a comprehensive genomics evaluation of the tumor immune microenvironment in The Cancer Genome Atlas dataset, discovering six immune subtypes of cancer. These and other findings are associated with survival and are being developed as biomarkers of...

Guorong Wu lab develops computational tools to understand brain function

April 8, 2019
Guorong Wu, PhD, and his lab are interested in developing cutting-edge computational tools to understand the brain, using state-of-the-art neuroimaging, genetics, and machine-learning technologies. With this in mind, they work to discover biomarkers of neurodegenerative diseases, characterize genetic influences on brain structure, and create personalized diagnostic engines.

Purvis Lab finds evidence that the human cell cycle is a series of uncoupled, memoryless phases

April 8, 2019
Time‐lapse imaging of cell‐cycle phase transitions reveals that phase durations are uncoupled and can be modeled as an Erlang process. Phase coupling can be forced by perturbing a strong cell‐cycle regulator acting on multiple phases.

Dr. Li Qian Appointed Associate Director of McAllister Heart Institute

March 15, 2019
Li Qian, PhD, associate professor of pathology and laboratory medicine, has been named the associate director of McAllister Heart Institute effective October 1, 2018.

Scientists train a computer to classify breast cancer tumors

December 7, 2018
In a study published in the journal NPJ Breast Cancer, Charles M. Perou, PhD, Melissa Troester, PhD, graduate student Heather D. Couture and colleagues reported they used a form of artificial intelligence to train a computer to identify certain features of breast cancer tumors from images. UNC Lineberger’s Charles M....