Bioinformatics, Biostatistics, and Data Analytics
Serving Center-Affiliate Members
Carolina Institute for Development Disabilities Bioinformatics and Statistical Analysis Core
Bioinformatics and Statistical Analysis Core, Carolina Institute for Developmental Disabilities, enhances the productivity of CIDD investigators and the quality of their research. The core assists IDDRC projects with study design, data management, and statistical analysis. Assistance ranges from simple consultation to answering specific data management or analysis questions, to collaborative involvement from the design stage through proposal writing, data collection and management, to the publication of results.
Center for Gastrointestinal Biology and Disease (CGIBD) Biostatistics and Clinical Research Core
The Biostatistics and Clinical Research Core provides state-of-the-art services from conception through completion of a project. Starting with consultation, study design, and data management, the Core then assists with the collection, analysis and integration of biological and epidemiological data. It provides assistance with database implementation and maintenance, web applications, validated and secure data capture, quality control, and statistical analysis. The Core provides an interface between basic scientists, clinical researchers, and informatics specialists to support translational research. Clinical research support includes IRB submission, contract negotiation, regulatory issues, IND, and tissue procurement. The Core maintains access to a set of large administrative databases utilized by members of CGIBD as well as trainees.
Lineberger Bioinformatics Core
The UNC Lineberger Bioinformatics Core provides the infrastructure for management and analysis of large scale research projects, and promotes individual researchers to tap the ever-growing data generated by new cancer research technologies.
The mission of the bioinformatics core is to support and enhance UNC Lineberger Comprehensive Cancer Center research activities by providing bioinformatics services and support.
Lineberger Biostatistics and Clinical Data Management
Lineberger Biostatistics and Clinical Data Management holds regularly scheduled walk-in clinics as well as in-depth consultations and data analysis services.
Open-Recharge
Biomedical Research Imaging Center (BRIC): Image Storage and Analysis
Biomedical Research Imaging Center (BRIC): Image Storage and Analysis core serves to develop new tools for image analysis and to support the image storage and analysis needs of scientists who use the BRIC facilities. So far, this core has developed various novel image segmentation, registration, and multivariate analysis methods, with applications to brain (including MCI, AD, Schizophrenia, and neonate study), heart, breast cancer, and prostate cancer. The facility is open to all users and accepts work from external entities.
Bioinformatics and Analytics Research Collaborative (BARC)
The Bioinformatics and Analytics Research Collaborative (BARC) at the University of North Carolina at Chapel Hill is a multi disciplinary center that aims to provide bioinformatics expertise and analysis to researchers across the university and beyond for high throughput data. We analyze, visualize, interpret, and manage genomic data while also offering custom solutions to fit our researchers’ needs. Additionally, the center strives to educate researchers on current tools and techniques, foster a collaborative environment by hosting workshops, working groups, and seminars, and improve existing tools and/or invent new tools and algorithms.
We offer a free initial consultation during which we discuss the client’s project and how to ensure they are able to maximize the information that they learn. Afterwards, depending on the scale of the project we provide services by the hours or staff for grant for projects longer than six months. Each project is assigned to a project coordinator and bioinformaticist. The project coordinator is the point of contact for the client and is responsible for updating them on the status of their project.
Clinical Genomic Analysis (GENYSIS) Core
The Clinical Genomic Analysis (GENYSIS) Core collaborates with other core facilities on campus to provide clinical researchers support with analyzing genomic data. Specifically, the GENYSIS Core can provide bioinformatics support by performing human genome alignment of sequence data generated from the HTSF (or other sequencing center) and variant calling via a custom in-house pipeline and variant analysis by correlation with participant phenotypic data, and analysis of called variants by highly trained staff. Reportable variants are discussed at a weekly meeting attended by MDs, PhDs, and genetic counselors. Additionally, the core can generate clinical-grade test report for the variants clinically confirmed in the MGL that can also be uploaded to Epic if the participant is a UNC patient and provide post-test services such as assisting the study, clinician, participants, and their family, including reviewing results, providing educational resources, and identifying appropriate clinical follow-up.
NC TraCS Data and Analytics
NC TraCS Data and Analytics offers services to help investigators mine and manage large and diverse data sets using advanced statistical, mathematical and computational techniques.
Access clinical and administrative data from UNC Health Care systems:
* Data Management
* Curated Data Sets
Access fully-hosted, web-based data management services to support clinical trials and clinical & translational research studies.
Ensure high quality data capture and compliance.
R. L. Juliano Structural Bioinformatics Core Facility
The R. L. Juliano Structural Bioinformatics Core Facility provides researchers with state-of-the-art consultation and collaboration in research studies requiring computational structural biology methods.
Research applications: Bioinformatics and Molecular Evolution analyses include multiple sequence alignments, phylogenetic analysis, and ancestral sequence predictions. Protein structure analysis includes protein fold determination, structure superimposition and comparison, homology modeling, active site identification, prediction of protein-protein interaction interfaces, mutation effects analysis, electrostatic surfaces, solvent accessibility calculations, subunit contact analysis, molecular dynamics calculations, free energies of binding, and docking of small molecules.
Instrumentation available: Researchers utilize hardware and software resources provided by ITS Research Computing. Available software packages include but are not limited to PyMOL, BLAST, T-Coffee, Discovery Studio, VMD, GROMACS and Amber.
Training resources: Training workshops on the following topics are available upon request: (1) Protein Data Bank (PDB), (2) PyMOL, and (3) Protein fold recognition and homology modeling. Individualized consultation and collaboration on research studies requiring computational structural biology methods is also available.
Eligible users: Researchers at UNC and other academic institutions or industrial laboratories.
Data Analytics
Abacus Evaluation Services
Abacus Evaluation can provide customized program evaluation, data analytics and visualization, network analysis, and more. Abacus aims to improve their clients impact and effectiveness.
Carolina Demography
Carolina Demography is housed with the Carolina Population Center. We use population-level data and other available research to provide context and perspective to people working to shape North Carolina’s future.
Our clients include local and state governments, foundations, businesses, schools, and not-for profit organizations who need accurate and specific information to make decisions and better understand their communities. We are non-partisan, rigorous, and approachable: Our team pairs a wide array of demographic and research consulting services with your subject matter expertise, leaving you with the data and analysis you need to make informed decisions.