Abdalla Alkhawaja (Bioinformatics and Computational Biology Graduate Student in the labs of Karen Mohlke and Terry Furey, UNC Genetics) and Dr. Kevin Currin are co-first authors on a newly published manuscript in the American Journal of Human Genetics titled “Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits”.
This publication describes mapping expression and chromatin accessibility QTLs across six liver cell types using single-nucleus multiome technology. The study demonstrates that this approach captures regulatory events often missed in bulk tissue analyses. Integrating these QTLs with relevant GWAS signals improved understanding of the mechanisms connecting genetic variants to cardiometabolic traits.