Research Interests
Key words: genetics of brain structure and development, neural progenitor cell models, computational biology
We are a lab exploring how variations in the genome change the structure and development of the brain, and in doing so, create risk for neuropsychiatric illness. We study genetic effects on multiple aspects of the human brain, from macroscale phenotypes like gross human brain structure measured with MRI to molecular phenotypes like gene expression and chromatin accessibility measured with genome-sequencing technologies. We also use neural progenitor cells as a modifiable and high fidelity model system to understand how disease-associated variants affect brain development.
Mentor Training:
- Faculty Mentoring Workshop for Biomedical Researchers
Training Program Affiliations:
- Bioinformatics and Computational Biology
- Genetics and Molecular Biology
- Neuroscience
Publications
Lab Members
If you are a grad student interested in a lab rotation, please email me. If you are interested in a postdoc in my lab, please email me with a cover letter and CV containing contact information for at least 3 references.
Jason Stein in UNC Genetics News

January 9, 2026
Cracking the Brain’s Code: New Sensor Wraps the Human Mind in 3D Insight
A new 3D sensor developed at UNC-Chapel Hill and designed to wrap around miniature brain models could give scientists an unprecedented view into human brain activity, accelerating drug discovery and opening new paths for understanding and treating psychiatric and neurological disorders.

January 9, 2026
UNC Researchers Build Stem Cell Models to Mimic Early Brain Development
A new study in the lab of Jason Stein, PhD, modeled brain development in a dish to identify cells and genes that influence infant brain growth, a trait associated with autism.

October 13, 2025
Department of Genetics Publications for September 2025
Department of Genetics faculty, postdocs, students and collaborators published 33 papers in September 2025.

October 2, 2025
Stein Receives New Grant from NIH Office of the Director
Dr. Jason Stein (Associate Professor, Genetics and Neuroscience) was awarded a new Other Transaction (OT2) from the NIH Office of the Director for his project titled “Modeling autism-associated gene-by-environment interactions in human brain organoids”.

July 1, 2025
Department of Genetics Publications for June 1st – 28th, 2025
Department of Genetics faculty, postdocs, students and collaborators published 25 papers during June 1st - 28th 2025.

May 9, 2025
Department of Genetics Publications for March 30th – April 26th, 2025
Department of Genetics faculty, postdocs, students and collaborators published 25 papers during March 30th - April 26th 2025.

May 5, 2025
UNC School of Medicine Names 2024-25 Yang Family Biomedical Scholars
Gaorav Gupta, MD, PhD, Misty Good, MD, MS, and Jason Stein, PhD, were selected as Yang Family Biomedical Scholars in the eighth installment of this annual School of Medicine award.

March 3, 2025
Department of Genetics Publications for February 2nd – March 1st, 2025
Department of Genetics faculty, postdocs, students and collaborators published 18 papers during February 2nd - March 1st 2025.

February 6, 2025
Department of Genetics Publications for January 19th – February 1st, 2025
Department of Genetics faculty, postdocs, students and collaborators published 17 papers during January 19th - February 1st 2025.

October 28, 2024
Department of Genetics Publications for October 13th – 26th, 2024
Department of Genetics faculty, postdocs, students and collaborators published 13 papers during October 13th - 26th, 2024.
