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Professor, Pathology & Laboratory Medicine Professor, Clinical Genetics

Research Interests

Keywords: Molecular genetic pathology

My major research interest is translation of new knowledge of the genetic causes of disease into diagnostic testing. The goal is to better characterize the spectrum, incidence and genotype-phenotype correlation of mutations associated with disease and to develop clinical testing in those genes with clinical utility. Dr. Weck has been co-investigator of several NIH-funded grants to implement exome/genome sequencing for diagnosis of genetic diseases from prenatal testing to adults, and is a member of the NHGRI Clinical Sequencing Evidence-Generating Research (CSER) consortium. She has been co-investigator of several institutional clinical trials to study the clinical utility of pharmacogenomics guided therapy and of the UNCseq tumor sequencing study to implement genomic sequencing for somatic mutation testing in cancer.  Dr. Weck’s laboratory has developed mutation testing for genes associated with primary ciliary dyskinesia, X-linked Alport syndrome, and focal segmental glomerulosclerosis (FSGS). The UNC molecular genetics laboratory is now one of the few laboratories in the country that offers clinical genetic testing for mutations associated with these diseases.

Mentor Training:


Awards and Honors:

2020 President, Association for Molecular Pathology

2018 Distinguished Service Award, College of American Pathologists

2008 Philip M. Blatt Award for Excellence in Resident Training in Clinical Pathology


PubMed Link

Karen Weck-Taylor in UNC Genetics News

Karen Weck-Taylor