Department of Genetics faculty, postdocs, students and collaborators published seventeen papers during Nov. 17-30, 2019.

Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile.
Behrens KA, Jania LA, Snouwaert JN, Nguyen M, Moy SS, Tikunov AP, Macdonald JM, Koller BH.
PLoS One. 2019 Nov 20;14(11):e0225449. doi: 10.1371/journal.pone.0225449. eCollection 2019.
PMID: 31747445

 

Borderline estrogen receptor-positive breast cancers in black and white women.
Benefield HC, Allott EH, Reeder-Hayes KE, Perou CM, Carey LA, Geradts J, Sun X, Calhoun BC, Troester MA.
J Natl Cancer Inst. 2019 Nov 19. pii: djz206. doi: 10.1093/jnci/djz206. [Epub ahead of print]
PMID: 31742342

 

Comparative genetic architectures of schizophrenia in East Asian and European populations.
Lam M, Chen CY, Li Z, Martin AR, Bryois J, Ma X, Gaspar H, Ikeda M, Benyamin B, Brown BC, Liu R, Zhou W, Guan L, Kamatani Y, Kim SW, Kubo M, Kusumawardhani AAAA, Liu CM, Ma H, Periyasamy S, Takahashi A, Xu Z, Yu H, Zhu F; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Indonesia Schizophrenia Consortium; Genetic REsearch on schizophreniA neTwork-China and the Netherlands (GREAT-CN), Chen WJ, Faraone S, Glatt SJ, He L, Hyman SE, Hwu HG, McCarroll SA, Neale BM, Sklar P, Wildenauer DB, Yu X, Zhang D, Mowry BJ, Lee J, Holmans P, Xu S, Sullivan PF, Ripke S, O’Donovan MC, Daly MJ, Qin S, Sham P, Iwata N, Hong KS, Schwab SG, Yue W, Tsuang M, Liu J, Ma X, Kahn RS, Shi Y, Huang H.
Nat Genet. 2019 Nov 18. doi: 10.1038/s41588-019-0512-x. [Epub ahead of print]
PMID: 3174083

 

Vaccine-Induced Skewing of T Cell Responses Protects Against Chikungunya Virus Disease.
Broeckel RM, Haese N, Ando T, Dmitriev I, Kreklywich CN, Powers J, Denton M, Smith P, Morrison TE, Heise M, DeFilippis V, Messaoudi I, Curiel DT, Streblow DN.
Front Immunol. 2019 Oct 31;10:2563. doi: 10.3389/fimmu.2019.02563. eCollection 2019.
PMID: 31736977

 

Common DNA sequence variation influences 3-dimensional conformation of the human genome.
Gorkin DU, Qiu Y, Hu M, Fletez-Brant K, Liu T, Schmitt AD, Noor A, Chiou J, Gaulton KJ, Sebat J, Li Y, Hansen KD, Ren B.
Genome Biol. 2019 Nov 28;20(1):255. doi: 10.1186/s13059-019-1855-4.
PMID: 31779666

 

SAME-clustering: Single-cell Aggregated Clustering via Mixture Model Ensemble.
Huh R, Yang Y, Jiang Y, Shen Y, Li Y.
Nucleic Acids Res. 2019 Nov 28. pii: gkz959. doi: 10.1093/nar/gkz959. [Epub ahead of print]
PMID: 31777938

 

Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice.
Smith CM, Proulx MK, Lai R, Kiritsy MC, Bell TA, Hock P, Pardo-Manuel de Villena F, Ferris MT, Baker RE, Behar SM, Sassetti CM.
MBio. 2019 Nov 26;10(6). pii: e02791-19. doi: 10.1128/mBio.02791-19.
PMID: 31772048

 

Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer.
Zhang H, Schaefer A, Wang Y, Hodge RG, Blake DR, Diehl JN, Papageorge AG, Stachler MD, Liao J, Zhou J, Wu Z, Akarca FG, de Klerk LK, Derks S, Pierobon M, Hoadley KA, Wang TC, Church G, Wong KK, Petricoin EF, Cox AD, Lowy DR, Der CJ, Bass AJ.
Cancer Discov. 2019 Nov 26. pii: CD-19-0811. doi: 10.1158/2159-8290.CD-19-0811. [Epub ahead of print]
PMID: 31771969

 

Characterization of Single Gene Copy Number Variants in Schizophrenia.
Szatkiewicz JP, Fromer M, Nonneman RJ, Ancalade N, Johnson JS, Stahl EA, Rees E, Bergen SE, Hultman CM, Kirov G, O’Donovan M, Owen M, Holmans P, Sklar P, Sullivan PF, Purcell SM, Crowley JJ, Ruderfer DM.
Biol Psychiatry. 2019 Oct 4. pii: S0006-3223(19)31748-2. doi: 10.1016/j.biopsych.2019.09.023. [Epub ahead of print]
PMID: 31767120

 

Determinants of QTL Mapping Power in the Realized Collaborative Cross.
Keele GR, Crouse WL, Kelada SNP, Valdar W.
G3 (Bethesda). 2019 May 7;9(5):1707-1727. doi: 10.1534/g3.119.400194.
PMID: 30914424

 

A Diallel of the Mouse Collaborative Cross Founders Reveals Strong Strain-Specific Maternal Effects on Litter Size.
Shorter JR, Maurizio PL, Bell TA, Shaw GD, Miller DR, Gooch TJ, Spence JS, McMillan L, Valdar W, Pardo-Manuel de Villena F.
G3 (Bethesda). 2019 May 7;9(5):1613-1622. doi: 10.1534/g3.118.200847.
PMID: 30877080

 

Whole Genome Sequencing and Progress Toward Full Inbreeding of the Mouse Collaborative Cross Population.
Shorter JR, Najarian ML, Bell TA, Blanchard M, Ferris MT, Hock P, Kashfeen A, Kirchoff KE, Linnertz CL, Sigmon JS, Miller DR, McMillan L, Pardo-Manuel de Villena F.
G3 (Bethesda). 2019 May 7;9(5):1303-1311. doi: 10.1534/g3.119.400039.
PMID: 30858237

 

Variant interpretation is a component of clinical practice among genetic counselors in multiple specialties.
Wain KE, Azzariti DR, Goldstein JL, Johnson AK, Krautscheid P, Lepore B, O’Daniel JM, Ritter D, Savatt JM, Riggs ER, Martin CL.
Genet Med. 2019 Nov 22. doi: 10.1038/s41436-019-0705-9. [Epub ahead of print]
PMID: 31754268

 

PIK3CA mutation in HPV-associated OPSCC patients receiving deintensified chemoradiation.
Beaty BT, Moon DH, Shen CJ, Amdur RJ, Weiss J, Grilley-Olson J, Patel S, Zanation A, Hackman TG, Thorp B, Blumberg JM, Patel SN, Weissler MC, Yarbrough WG, Nathan C S, Parker J, Hayes DN, Weck KE, Ramkissoon LA, Mendenhall WM, Dagan R, Tan X, Gupta GP, Chera BS.
J Natl Cancer Inst. 2019 Nov 20. pii: djz224. doi: 10.1093/jnci/djz224. [Epub ahead of print]
PMID: 31747025

 

Pinopodes: Recent advancements, current perspectives, and future directions.
Quinn KE, Matson BC, Wetendorf M, Caron KM.
Mol Cell Endocrinol. 2019 Nov 15:110644. doi: 10.1016/j.mce.2019.110644. [Epub ahead of print] Review.
PMID: 31738970

 

Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China: a study protocol for a three-arm cluster randomized controlled trial.
Zhang TP, Yang F, Tang W, Alexander M, Forastiere L, Kumar N, Li K, Zou F, Yang L, Mi G, Wang Y, Huang W, Lee A, Zhu W, Vickerman P, Wu D, Yang B, Christakis NA, Tucker JD.
Infect Dis Poverty. 2019 Aug 16;8(1):76. doi: 10.1186/s40249-019-0581-1.
PMID: 31426869

 

Xenopus: Experimental Access to Cardiovascular Development, Regeneration Discovery, and Cardiovascular Heart-Defect Modeling.
Hoppler S, Conlon FL.
Cold Spring Harb Perspect Biol. 2019 Nov 25. pii: a037200. doi: 10.1101/cshperspect.a037200. [Epub ahead of print]
PMID: 31767648