Research Interests
Keywords: Genome stability, DNA Repair, APOBEC, Aging, Bats, Comparative genomics, Parasite fungi-host interaction, Applications for NGS, Multi-omics.
Dr. Mieczkowski’s background is in DNA repair, DNA recombination, DNA replication, eukaryotic genome stability, and DNA structural organization. He has investigated various aspects of genome stability and DNA repair using standard genetics methodology, next-generation sequencing, and microarray technology. He was involved in constructing the custom microarray printer used for developed methods to analyze copy number variations and genome rearrangements in model organisms. He was interested in developing genome stability and mutagenesis research applications in the early stage of next-generation sequencing evolution. He laid the groundwork for methodology and workflow used by UNC High Throughput Sequencing Facility and the development of applications for amplicon sequencing and automation for various NGS applications. He is part of many projects that use next-generation sequencing as a primary tool for research. Currently, his research is focused on the multi-omic analysis of bats as a model organism for aging, hibernation, and pathogen-host interaction.
Dr. Mieczkowski is the Technologies Director for the High-Throughput Sequencing Facility (HTSF) at UNC. He provides consultations to plan and design new studies. This includes selecting the best technology platform to meet an investigator’s research needs. He also takes a lead role in identifying, testing, and rolling out new cutting-edge technologies that keep the HTSF at the forefront of genomics research.
Publications
Piotr Mieczkowski in UNC Genetics News

December 16, 2025
Department of Genetics Publications for November 2025
Department of Genetics faculty, postdocs, students and collaborators published 29 papers in November 2025.

October 29, 2025
Department of Genetics Hosts Wake Tech Community College (WTCC) Stem Academic and Research Training (START) Program Students
On October 24, 2025, the Department of Genetics hosted a group of 10 students from Wake Tech Community College (WTCC) who are part of the Stem Academic and Research Training (START) program.

October 13, 2025
Department of Genetics Publications for September 2025
Department of Genetics faculty, postdocs, students and collaborators published 33 papers in September 2025.

July 1, 2025
Department of Genetics Publications for June 1st – 28th, 2025
Department of Genetics faculty, postdocs, students and collaborators published 25 papers during June 1st - 28th 2025.

June 3, 2025
Department of Genetics Publications for April 27th – May 31st, 2025
Department of Genetics faculty, postdocs, students and collaborators published 42 papers during April 27th - May31st 2025.

January 6, 2025
Department of Genetics Publications for December 22nd, 2024 – January 4th, 2025
Department of Genetics faculty, postdocs, students and collaborators published 11 papers during December 22nd, 2024 - January 4th, 2025.

June 18, 2024
Mieczkowski Awarded NCBC-IIG Equipment Grant
Dr. Piotr Mieczkowski (Professor, Genetics) was awarded an equipment grant from the North Carolina Biotechnology Center (NCBC) for his proposal titled “Enhancing the High Throughput Sequencing Facility at UNC: Upgrading from Fluent 1080 to Tecan DreamPrep NGS Workstation for Improved Capability”.

June 10, 2024
Department of Genetics Publications for May 12th – June 8th, 2024
Department of Genetics faculty, postdocs, students and collaborators published 23 papers during May 12th - June 8th 2024.

April 29, 2024
Department of Genetics Publications for April 14th – 27th, 2024
Department of Genetics faculty, postdocs, students and collaborators published 12 papers during April 14th - 27th 2024.

July 30, 2023
Department of Genetics Publications for July 16th – 29th, 2023
Department of Genetics faculty, postdocs, students and collaborators published 8 papers during July 16th - 29th 2023.
