Research Interests
Keywords: Genome stability, DNA Repair, APOBEC, Aging, Bats, Comparative genomics, Parasite fungi-host interaction, Applications for NGS, Multi-omics.
Dr. Mieczkowski’s background is in DNA repair, DNA recombination, DNA replication, eukaryotic genome stability, and DNA structural organization. He has investigated various aspects of genome stability and DNA repair using standard genetics methodology, next-generation sequencing, and microarray technology. He was involved in constructing the custom microarray printer used for developed methods to analyze copy number variations and genome rearrangements in model organisms. He was interested in developing genome stability and mutagenesis research applications in the early stage of next-generation sequencing evolution. He laid the groundwork for methodology and workflow used by UNC High Throughput Sequencing Facility and the development of applications for amplicon sequencing and automation for various NGS applications. He is part of many projects that use next-generation sequencing as a primary tool for research. Currently, his research is focused on the multi-omic analysis of bats as a model organism for aging, hibernation, and pathogen-host interaction.
Dr. Mieczkowski is the Technologies Director for the High-Throughput Sequencing Facility (HTSF) at UNC. He provides consultations to plan and design new studies. This includes selecting the best technology platform to meet an investigator’s research needs. He also takes a lead role in identifying, testing, and rolling out new cutting-edge technologies that keep the HTSF at the forefront of genomics research.
Mentor Training:
- Bias 101
Publications
Piotr Mieczkowski in UNC Genetics News

July 14, 2022
Genetics Faculty Awarded Creativity Hub from UNC VCR’s Office
The Office of the Vice Chancellor for Research announced that AIxB: Building a collaborative ecosystem for innovation in Artificial Intelligence and the Biological Sciences is the winner of this year’s Creativity Hub Award. Faculty from Genetics include Dr. Corbin Jones (PI, Professor, Biology and Genetics), Dr. Piotr Mieczkowski (co-I, Professor, Genetics), Dr. Bob Duronio (co-I, …

July 5, 2022
Department of Genetics Publications for June 19th – July 2nd, 2022
Department of Genetics faculty, postdocs, students and collaborators published 11 papers during June 19th – July 2nd, 2022.

April 25, 2022
Department of Genetics Publications April 10th – 23rd, 2022
Department of Genetics faculty, postdocs, students and collaborators published 18 papers during April 10th – 23rd, 2022.

January 14, 2022
Piotr Mieczkowski, PhD, Awarded Boost funding from SOM Dean’s Office
Dr. Piotr Mieczkowski (Associate Professor, Department of Genetics; Technical Director, High Throughput Sequencing Facility) was awarded Boost funding from the UNC SOM Dean’s Office for his project “First Multi-Omic Study of Bat Longevity as a Model for Neurodegenerative Diseases”.

January 3, 2022
Department of Genetics Publications December 12th, 2021 – January 1st, 2022
Department of Genetics faculty, postdocs, students and collaborators published 14 papers during December 12th, 2021 – January 1st, 2022.

November 15, 2021
Department of Genetics Publications October 31st – November 13th 2021
Department of Genetics faculty, postdocs, students and collaborators published 12 papers during October 31st – November 13th 2021. A multi-omic single-cell landscape of human gynecologic malignancies. Regner MJ, Wisniewska K, Garcia-Recio S, Thennavan A, Mendez-Giraldez R, Malladi VS, Hawkins G, Parker JS, Perou CM, Bae-Jump VL, Franco HL. Mol Cell. 2021 Nov 1:S1097-2765(21)00842-X. doi: …

May 2, 2021
Department of Genetics Publications for April 18 – May 1, 2021
Department of Genetics faculty, postdocs, students and collaborators published thirteen papers during April 18 – May 1, 2021.

April 19, 2021
Department of Genetics Publications for April 4-17, 2021
Department of Genetics faculty, postdocs, students and collaborators published fifteen papers during April 4-17, 2021. Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors. Ahmed SK, Haese NN, Cowan JT, Pathak V, Moukha-Chafiq O, Smith VJ, Rodzinak KJ, Ahmad F, Zhang S, Bonin KM, Streblow AD, Streblow CE, Kreklywich CN, Morrison C, Sarkar S, Moorman N, …

November 30, 2020
Department of Genetics Publications for Nov. 15-28, 2020
Department of Genetics faculty, postdocs, students and collaborators published nine papers during November 15-28, 2020.

November 20, 2020
Genetics Faculty Members Hoadley, Mieczkowski, Parker, Perou, Sullivan and Ting Named to Clarivate’s 2020 List of Highly Cited Researchers
Drs. Katie Hoadley (Assistant Professor), Piotr Mieczkowski (Associate Professor), Joel Parker (Associate Professor), Chuck Perou (Professor), Patrick Sullivan (Professor) and Jenny Ting (Professor) have been recognized as 2020 Highly Cited Researchers.