The National Human Genome Research Institute (NHGRI) has published “Strategic vision for improving human health at The Forefront of Genomics” in the latest issue of Nature. Through a planning process of more than 50 events (workshops, conferences, webinars) over the last two years, the institute collected input from many stakeholders to formulate this vision. Four areas form the foundation of the strategy: guiding principles and values, robust foundation for genomics, breaking down barriers and compelling genomics research projects.