Procedure-only CURE Studies
Leuk Study
| Goal | To investigate new methods of activating resting HIV infected cells in the laboratory. |
| Who is eligible to participate | HIV + individuals > 18 years of age; VL < 50; CD4 >300; on ART > 6 months |
| Procedure | Leukapheresis |
| Duration | 2 visits (screening and leukapheresis). Duration is up to 3 years |
| Compensation | Screening visit – $25, Leukapheresis – $150. Travel & parking compensation are offered as well. |
Single Blood Draw Study
| Goal | Obtain blood samples to evaluate normal immune and virologic functions responses as well as to study novel assays in virally suppressed HIV-1 positive person. |
| Who is eligible to participate | HIV+ ; 18-65 years of age; VL< 50; and on ART for 24 months |
| Procedure | Blood draws (up to 200 mL) |
| Duration | 2 visits (screening and blood draw visit). |
| Compensation | Screening visit – $25, Blood draw visit – $50 if you donate < 100 mL, $100 if you donate > 100 mL. Travel & parking compensation are offered as well. |
Serial Blood Draw Study
| Goal | Obtain serial blood samples from suppressed HIV infected participants to determine baseline variability in immune responses and inform what constitutes a significant change in T cell or immune responses following interventions. |
| Who is eligible to participate | HIV+ > 18 years of age; On ART > 24 months |
| Procedure | Blood draws |
| Duration | Up to 3 months with visits scheduled once a week for consecutive four weeks and then once a month for two consecutive months |
| Compensation | $35 each time you donate blood. Travel & parking compensation are offered as well. |
The Aging Study
| Goal | Obtain blood sample to investigate how HIV serostatus and age impacts levels of mitochondrial function in CD8 T cells and CD8 memory phenotype. Secondary objective is to investigate how HIV serostatus and age impact mitochondrial function in CD8 T cells such as the generation of energy to support antigen-driven proliferation. |
| Who is eligible to participate | HIV + & HIV – participants; >18 years of age; HIV + individuals must have VL <50 copies/ml for > 24 months, and CD4 >300 |
| Procedure | Blood draws |
| Duration | Up to 2 visits |
| Compensation | Screening visit – $50, Blood draw visit – $100. Travel & parking compensation are offered as well. |
HIV Reservoir in Women
| Goal | To characterize HIV reservoir size, stability, and persistence in women as well as evaluate approaches to disrupt HIV latency in women. |
| Who is eligible to participate | HIV-1 infected women, ≥18 and ≤ 62 years of age, on stable cART with HIV-1 RNA levels < 50 copies/mL for at least 12 months, as measured on standard HIV RNA assays. Eligible participants must have a CD4 cell count ≥ 300 |
| Procedure | Leukapheresis procedure and optional sigmoidoscopy procedure |
| Duration | Up to 3 years |
| Compensation | Visits – $50, Leukapheresis – $200, Sigmoidscopy – $300. Travel & parking compensation are offered as well. |