About

Yash N. Agrawal, MD is a breast medical oncologist and physician-scientist at the UNC Lineberger Comprehensive Cancer Center and Assistant Professor in the Division of Oncology at the UNC School of Medicine. His research focuses on integrating transcriptomic and multiomic data with survival and patient outcomes to identify biomarkers of treatment response and resistance in breast cancer, with a special focus on breast cancer in older adults and in hormone receptor–positive/HER2-negative (HR+/HER2–) breast cancer. Dr. Agrawal has led and contributed to correlative analyses of trials from international cooperative groups including GEICAM and SOLTI to characterize the interaction between CDK4/6 inhibitors + endocrine therapy, intrinsic subtype, and the immune microenvironment, and how these biological features might predict survival benefit. His work has also extended to the preclinical setting, including initial multiomic analysis of a heterogeneous genetically engineered mouse model of breast cancer, and more recently application of cutting-edge transcriptomics and statistical modeling to identify candidate resistance mechanisms of endocrine therapy and CDK4/6 inhibitor treatment. In collaboration with Drs. Charles Perou, Lisa Carey, and Hyman Muss, Dr. Agrawal has spearheaded projects studying how aging and senescence influence the tumor immune microenvironment in breast cancer. This work has been supported by a Pope Fellowship Award and most recently the 2025 Conquer Cancer Foundation Young Investigator Award in Geriatric Oncology, and is notable for its integration of RNA sequencing from large patient cohorts with novel spatial transcriptomics and peripheral immune profiling. Dr. Agrawal is an active collaborator with GEICAM and SOLTI cooperative groups, the Translational Breast Cancer Research Consortium (TBCRC), and the Alliance for Clinical Trials in Oncology, in computational discovery efforts with a goal of translating these findings into clinically meaningful outcomes. He has presented nationally at the San Antonio Breast Cancer Symposium and the ASCO Annual Meeting, and his publications have appeared in journals such as JCO Precision Oncology, NPJ Breast Cancer, and ESMO Open. He is also dedicated to education, serving as a mentor for residents and fellows at UNC, and having co-authored Agrawal’s Medical Oncology Board Review to support trainee and physician preparation for oncology board certification.