William Fischer, MD

William Fischer, MD

919-843-9108
@WFischerII



Assistant Professor of Medicine

Specialty Areas: Severe Viral Infections, Acute Respiratory Distress Syndrome, Critical Care Medicine

Chronology: BS: Bates College, Lewiston, ME (1998); MD: University of North Carolina at Chapel Hill (2004); Residency:  Johns Hopkins Hospital, Baltimore, MD (2007); Assistant Chief of Service:Johns Hopkins Hospital, Baltimore, MD  (2008-2009);  Fellowship: Johns Hopkins Hospital, Baltimore, MD (2012)

Research Interests:

Critical Care Virology

DSC01307 - Version 2  Fischer 1

Severe acute viral infections are one of the world's most common causes of hospitalization and mortality with worse outcomes disproportionately affecting resource constrained countries.  In the past 15 years we have witnessed the emergence or re-emergence of several viral pathogens that threaten global public health including SARS, pandemic H1N1 Influenza, MERS-CoV, and most recently Ebola.  The focus of our group is to better understand host factors that underly susceptibility to severe viral infections, evaluate novel therapeutic interventions to improve mortality from severe viral infections, and to operationalize these interventions in resource constrained settings.

Recent Publications:

  1. Clinical Management of Severe Acute Respiratory Infection when Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection Is Suspected.  WHO Guidelines:  http://www.who.int/csr/disease/coronavirus_infections/case-management-ipc/en/ 
  2. Fischer, W., Weber, D., and Wohl, D.  Personal Protective Equipment - Protecting Healthcare Providers in an Ebola Outbreak.  Journal of Clinical Therapeutics. 2015 In press.
  3. Weber, D. Fischer, W. Wohl, D. and Rutala, William.  Protecting Healthcare Personnel Against Acquisition of Ebola Virus Disease.  Infection Control and Hospital Epidemiology. 2015 In press
  4. Fischer, W., King, L.S., Lane, A., and Pekosz, A.  Restricted Replication of the Live Attenuated Influenza A Vaccine during Infection of Primary Differentiated Human Nasal Epithelial Cells. In press Vaccine.
  5. Fischer, W., Uyeki, T., Brooks, J., and Tauxe, R. Ebola - What a Clinician Needs to Know. In press, American Journal of Infection Control May 2015
  6. Lamontagne, F., Clement, C., Fletcher, T, Shevin J, Fischer II, W. and Fowler, R. Doing Today’s Work Superbly Well – Treating Ebola with Current Tools. NEJM 2014 In press.
  7. Bah, Elhadj I., L., Marie-Claire, Fletcher, T., Jacob, S., Brett-Major, D., Sall, A., Shindo, N., Fischer, W. et al.  Clinical Presentation and Outcomes in Patients admitted with Ebola Virus Disease in Conakry, Guinea. NEJM 2015; 372:40-47.  PMID 25372658
  8. Fowler, R.; Fletcher, T.; Fischer, W. et al.  Caring for Critically Ill Patients with Ebola Virus Disease: Perspectives from West Africa. American Journal of Respiratory and Critical Care Medicine 2014 October 23; 371(17):1565-6.  PMID 25251518
  9.  Fischer, W., Gong, M., Bhagwanjee, S., Sevransky, J. Global Burden of Influenza as a Cause of Cardiopulmonary Morbidity and Mortality.  Global Heart 2014 September 9(4):325-336.
  10. Fischer, W. Hyne, N., and Perl, T. Protecting Healthcare Workers from Ebola – PPE Is Critical But Its Not Enough. Annals of Internal Medicine 2014 November 18;161(10):753-4 PMID 25255746
  11. Fischer, W., Weber, D., and Wohl, D.  Personal Protective Equipment - Protecting Healthcare Providers in an Ebola Outbreak.  Journal of Clinical Therapeutics. 2015 In press.
  12. Dunning, J., and Fischer, W. Ebola:  the battle plan must include specific treatments. Lancet. 2014 In press. PMID 25534189
  13. Brett-Major, DM, Jacob, ST, Jacquerioz, FA, Risi, GF, Fischer WA 2nd, et al. Being Ready to Treat Ebola Virus Disease Patients. Am J Trop Med Hyg. 2014 In press.  PMID 2551072
  14. Fischer, W., Brighton, L., Jaspers, I., Live Attenuated Influenza Vaccine Strains Elicit a Greater Innate Immune Response than Antigenically-Matched Seasonal Influenza Viruses during Infection of Human Nasal Epithelial Cells. Vaccine 2014 Mar 26;32(15):1761-7. PMC3979967
  15. Muller L, Brighton L, Carson J, Fischer W and Jaspers I. Culturing of Re-Differentiated Human Nasal Epithelial Cells at the Air Liquid Interface. J Vis Exp. 2013. PMC3938966