Research News

Klara Klein, MD, PhD Klara R. Klein, MD, PhD, fellow in the division of endocrinology and metabolism and trainee in the UNC Physician Scientist Training Program, and John Buse, MD, PhD, chief of the division of endocrinology and metabolism, are authors of a new study published in BMJ Open Diabetes Research and Care. Hemoglobin glycation index … Read more

Carla Ribeiro, PhD Carla Ribiero, PhD, professor of medicine in the division pulmonary and critical care medicine, expands the understanding of how airway inflammation improves CFTR rescue and may benefit cystic fibrosis patients, in a new review published in Cells. The cystic fibrosis transmembrane conductance regulator (CFTR) protein is responsible for regulating the proper flow … Read more

Lisa Carey, MD, FASCO Lisa A. Carey, MD, FASCO, the L. Richardson and Marilyn Jacobs Preyer Distinguished Professor for Breast Cancer Research, Division of Oncology and Deputy Director of Clinical Sciences for the Lineberger Comprehensive Cancer Center, discusses findings from a pooled analysis of the MONALEESA-2, -3, and -7 trials. Among the findings was a consistent … Read more

Anne Peery, MD, MSCR Anne Peery, MD, MSCR, associate professor in the Division of Gastroenterology and Hepatology, is the corresponding author of a new article, “Burden and Cost of Gastrointestinal, Liver and Pancreatic Diseases in the United States: Update 2021,” published October 19 in Gastroenterology. The study concluded, “Gastrointestinal diseases are responsible for millions of … Read more

A single dose of REGEN-COV, a combination monoclonal antibody therapy, reduced the risk of COVID-19 by 81.6% several months after a single dose. UNC School of Medicine’s Myron Cohen, MD, leads monoclonal antibody research efforts as part of the NIH-sponsored COVID Prevention Network. Myron Cohen, MD Regeneron Pharmaceuticals, Inc. announced additional positive results from a … Read more

The NC TraCS Institute has awarded John A. Batsis, MD, and the Division of Geriatric Medicine a 1-year, team science grant to study the early detection of sarcopenia.

Hyman Muss, MD Hyman Muss, MD, the Mary Jones Hudson Distinguished Professor of Geriatric Oncology in the Division of Oncology, recently received three research awards. From the Breast Cancer Research Foundation (BCRF), Muss received $190,000 in funding for “p16INK4a Expression, Chemotherapy Toxicity, and Aging in Women with Breast Cancer.” There is significant variability in chemotherapy-related toxicity … Read more

Jonathan Serody, MD, the Elizabeth Thomas Professor of Medicine, Microbiology and Immunology, and chief of the Division of Hematology, received an NIH (NHLBI) R01 grant of $3.4M to evaluate epigenetic changes in innate lymphoid cells as a mediator of acute Graft-Versus-Host Disease (GvHD) after stem cell transplantation. The grant is in collaboration with Samantha Pattenden, … Read more

Jonathan Parr, MD A major tool against malaria in Africa has been the use of rapid diagnostic tests, which have been part of the “test-treat-track” strategy in Ethiopia, the second most-populated country in Africa. But researchers studying blood samples from more than 12,000 individuals in Ethiopia now estimate these tests missed nearly 10% of malaria … Read more

Tracy Rose, MD, MPH A new study is the first to report the beneficial use of chemotherapy plus immunotherapy before surgical removal of the bladder in muscle-invasive bladder cancer (MIBC). Researchers at the UNC Lineberger Comprehensive Cancer Center led the study, reporting that the regimen reduced the invasiveness of the cancer in 56 percent of … Read more

Jessica Lin, MD MSCR CRISPR-based diagnostics are a new class of highly sensitive and specific assays with multiple applications in infectious disease diagnosis. SHERLOCK, or Specific High-Sensitivity Enzymatic Reporter UnLOCKing, is one such CRISPR-based diagnostic that combines recombinase polymerase pre-amplification, CRISPR-RNA base-pairing, and LwCas13a activity for nucleic acid detection. Researchers from the division of infectious … Read more

Carlton Moore, MD, MS Carlton Moore, MD, professor of medicine in the division of infectious diseases, is first author of a retrospective observational study design of patients hospitalized in 2015 from four hospitals participating in the Atherosclerosis Risk in Communities (ARIC) study. Using free-text clinical notes and reports from hospitalized patients, the study team wanted … Read more