ADEPT
Aspirin Dose Escalation for the Prevention of recurrent preterm delivery Trial (ADEPT)
The ADEPT trial is looking to see if 162 milligrams (mg) or 81 mg of aspirin will help lower the risk of having a repeat preterm delivery.
Aspirin is a medication that has anti-inflammatory properties and prevents blood clots. Taking 81 milligrams (mg) of aspirin per day has already been shown to decrease or delay the risk of preeclampsia (high blood pressure problems) and pre-term births in pregnant individuals. Some studies indicate that a higher dose may further decrease these risks. The ADEPT Trial is studying these benefits in increased dosage!
You may be right for this study if:
- You are at least 10 weeks but not more than 16 weeks pregnant with one baby
- You delivered more than five weeks early (before 35 weeks) in your most recent pregnancy
This study is not right for you if:
- You are having two or more babies
- You have not had a pre-term birth
If you’re not sure if you qualify please contact us so we can help guide you.
*This study will be recruiting through 2028 and participants will be compensated for their time*
More Information
This study is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Conducted by the NICHD Maternal-Fetal Medicine Units (MFMU). All biostatistical information is the responsibility of the Biostatistical Coordinating Center (BCC) at George Washington University.
IRB#: 25-1069
The button above will redirect you to our secure data collection form
morbidity and mortality from preeclampsia: U.S. preventive services task force recommendation
statement. Ann Intern Med. 2014;161(11):819–826. doi: 10.7326/M14-1884.
ACOG. Low-dose aspirin use during pregnancy. https://www.acog.org/clinical/clinicalguidance/committee-opinion/articles/2018/07/low-dose-aspirin-use-during-pregnancy. Accessed
April 22, 2020.
CLASP: A randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia
among 9364 pregnant women. CLASP (collaborative low-dose aspirin study in pregnancy) collaborative
group. Lancet. 1994;343(8898):619–629.
Shanmugalingam R, Wang X, Munch G, et al. A pharmacokinetic assessment of optimal dosing,
preparation, and chronotherapy of aspirin in pregnancy. Am J Obstet Gynecol. 2019;221(3):255.e1–
255.e9. doi: 10.1016/j.ajog.2019.04.027.
https://www.who.int/news-room/fact-sheets/detail/preterm-birth
