PRECEDE
Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial (PRECEDE)
The PRECEDE trial is looking to see if adding an extra antibiotic (azithromycin) to the different antibiotics already given at the time of a planned
cesarean delivery reduces postpartum infection rates for participants and their newborns.
Azithromycin:
- Commonly used antibiotic, sometimes called a Z-Pak
- Approved for use in pregnant women intravenously (IV)
- A standard medication used to prevent infections in laboring women having unscheduled or emergency cesarean delivery
However, there have not been studies done to determine the possible benefits of azithromycin use in women with scheduled cesareans and who are not considered to be in labor. We hope that PRECEDE will fill this gap in research to prevent delivery related infections.
You may be right for this study if:
- You are pregnant with one or two babies
- You are at least 23 weeks pregnant
- You are planning to have a cesarean delivery
This study is not right for you if:
- You are planning to labor and have a vaginal delivery
- You are having triplets or more than two babies
If you are not sure if you qualify please contact us so we can help guide you.
*This study will be recruiting through spring 2028 and participants will be compensated for their time*
More Information
This study is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health (NIH). Conducted by the NICHD Maternal-Fetal Medicine Units (MFMU). All biostatistical information is the responsibility of the Data Coordinating Center (DCC) at George Washington University.
IRB#: 24-2210
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