Hyejung Won & Jason Stein Publish in Cell
January 16, 2018
Jason Stein and Hyejung Won recently published an article in Cell on the dynamic landscape of open chromatin during human neurogenesis.
Category: News
UNC Scientists Take a Big Step toward Building a Better Opioid
January 12, 2018
In a paper published in Cell, UNC School of Medicine researchers led by Bryan Roth, MD, PhD, show how to activate only one kind of brain receptor vital for pain relief. This receptor is not involved in addiction or respiratory depression that leads to death – the most severe side effects of opioid use.
Song Lab Publishes on Discovery of a Long-Distance Brain Circuit in Cell Stem Cell
November 3, 2017
In a new study published in Cell Stem Cell, UNC School of Medicine neuroscientist Juan Song and colleagues discovered a long-distance brain circuit that controls the production of new neurons in the hippocampus. This story is featured as the Cover Story in the current issue of Cell Stem Cell.
Garret Stuber, PhD, Receives NIH Merit Award
September 29, 2017
Garret Stuber, PhD, received an NIH Merit Award for his NIH grant to study midbrain neural circuits that orchestrate cue-reward associations. Merit awards provide long-term, stable support to investigators whose research competence and productivity are distinctly superior and who are likely to continue to perform in an outstanding manner. This grant, which is funded by NIDA, provides stable support for this project for 10 years.
Taylor Lab Publishes in Nature Communications
September 27, 2017
Anne Marion Taylor’s lab publishes in Nature Communications on the cellular mechanisms of circuit remodeling following axon damage in the mammalian central nervous system.
Faulty cell signaling derails cerebral cortex development, could it lead to autism?
September 21, 2017
Anton Lab Researchers pinpoint signaling problems in the progenitor cells crucial for proper neuron generation and organization.
UNC named NIH Autism Center of Excellence for third time
September 19, 2017
As part of a five-year, $7.5 million award, UNC researchers led by Joseph Piven, MD, will follow up on innovative imaging studies to create interventions to help children with autism.
NIH grant to help UNC researchers explore microRNA as route to Alzheimer’s therapy
September 14, 2017
The National Institute on Aging awarded a $2.6-million, five-year grant to UNC’s Mohanish Deshmukh’s lab to explore miR-29, a key molecule that helps mature brain cells avoid death.
Unraveling Alzheimer’s: New Study Documents How Brain Cells Go Bad
September 7, 2017
In a first-of-its-kind study, UNC researchers show how a damaging cascade of events inside brain cells – and related to Alzheimer’s disease – can be stopped or reversed.
Gupton Lab Featured on Cover of Molecular Biology of the Cell
September 1, 2017
The axon guidance cue netrin-1 and its receptor DCC promote axon branching in developing cortical neurons. In this study, we detail a novel molecular mechanism by which the brain-enriched E3 ubiquitin ligase TRIM9 orchestrates multimerization of DCC, requisite activation of FAK and Src family kinases, and increases in exocytic vesicle fusion, all during netrin-dependent neuronal morphogenesis. We are the first to show that non-degradative ubiquitination of a receptor alters kinase activation and signaling pathways during morphogenesis.