Memories can last a lifetime, but the neuronal synapses that store memories are made of macrolmolecules such as proteins that undergo synthesis and degradation on the scale of hour to days. The Huganir Lab, in which Dieiring was recently a postdoctoral scholar, hypothesized that a population of extremely long-lived proteins may reside at synapses, forming part of the substrate for long-term storage of memories. Here they have used metabolic labeling of mice and cultured neurons, combined with mass spectrometry to identify the synaptic long-lived proteome.
The UNC School of Medicine has awarded the 18th Perl-UNC Neuroscience Prize to Winrich Freiwald, PhD, of The Rockefeller University and Doris Y. Tsao, PhD, of the California Institute of Technology for the discovery of brain mechanisms of face recognition.
Freiwald and Tsao will visit Chapel Hill on April 12 to receive the prize – a $20,000 award – and give a lecture on their work at 3 p.m. in room G202 in the Medical Biomolecular Research Building (MBRB).
In a paper published in Cell, UNC School of Medicine researchers led by Bryan Roth, MD, PhD, show how to activate only one kind of brain receptor vital for pain relief. This receptor is not involved in addiction or respiratory depression that leads to death – the most severe side effects of opioid use.
In a new study published in Cell Stem Cell, UNC School of Medicine neuroscientist Juan Song and colleagues discovered a long-distance brain circuit that controls the production of new neurons in the hippocampus. This story is featured as the Cover Story in the current issue of Cell Stem Cell.
Garret Stuber, PhD, received an NIH Merit Award for his NIH grant to study midbrain neural circuits that orchestrate cue-reward associations. Merit awards provide long-term, stable support to investigators whose research competence and productivity are distinctly superior and who are likely to continue to perform in an outstanding manner. This grant, which is funded by NIDA, provides stable support for this project for 10 years.