Limited Submission Deadline: NIH Alzheimer’s Disease Research Centers (P30)

Limited Submissions: Internal Call for Proposals

National Institute of Health
Alzheimer’s Disease Research Centers

(P30 Clinical Trial Not Allowed)
UNC Internal deadline: 11:59PM, Monday, June 1, 2020

 

*Please distribute to relevant faculty*

Key Dates

UNC Internal Deadline: 11:59PM, Monday, June 1, 2020

NIH LOI Deadline: August 15, 2020

NIH Application Deadline: September 15, 2020

Important Information

• Number of Applications per Institution: Organizations may only submit one nomination.

To Apply

Submit the following (in ONE .pdf)  to the Office of Research Development limited submissions inbox Limited_Submissions@unc.edu by 11:59PM, Monday, June 1, 2020.

1. PI/Proposed team member’s CV/NIH formatted biosketch (five-page maximum)
2. Project Summary (two-page maximum)
3. List of potential/committed collaborators (internal and external to UNC)
4. Names of three internal (to UNC) experts who could speak knowledgeably about the candidate’s research and who could potentially serve on an internal review panel.
   • Please do not include the names of faculty named on the project, chairs, deans, directors, direct reports, or others who have a conflict of interest. 
   • Please notify all potential internal reviewers before submitting the pre-proposal packet to ORD.

Award Information

Award Budget: Applications may request a budget of up to $2 million in direct costs per year.

Award Project Period: The maximum project period is 5 years.

Cost Sharing: Not required.

Program Overview

This Funding Opportunity Announcement (FOA) invites applications for P30 Alzheimer’s Disease Research Centers (ADRCs). NIA-designated ADRCs serve as major sources of discovery into the nature of Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD) and into the development of more effective approaches to prevention, diagnosis, care, and therapy. They contribute significantly to the development of shared resources that support dementia-relevant research, and they collaborate and coordinate their research efforts with other NIH-funded programs and investigators.

 

The objectives of the NIA Alzheimer’s Centers Program are to foster highly interactive, cutting-edge Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD) research through the following:

• Create an environment that supports innovative research that has a significant impact on the field of dementia research and treatment;
• Provide core services that leverage funding and unique expertise;
• Raise awareness and interest in fundamental, clinical, and translational dementia research at institutions, as well as locally, regionally, and nationally;
• Foster interdisciplinary collaborations, especially in emerging areas of research, to catalyze new ideas and scientific approaches;
• Attract and retain a diverse group of early stage investigators and investigators new to dementia research;
• Promote the translation of scientific discoveries from bench to bedside to community that improve public health and provide an opportunity for feedback, including validation and effectiveness measures;
• Enable bi-directional translation aimed at accelerating the development of effective treatment and prevention for AD patients at all stages of the disease;
• Provide rapid and broad sharing of analytic and research tools, as well as data, as appropriate and as consistent with achieving the goals of the program; and
• Enhance dementia-related research education opportunities for people with dementia, their care partners, students, scientists, and clinicians.

NIA’s support of Alzheimer’s Centers is intended to foster excellence in research across a broad spectrum of scientific and medical concerns relevant to dementia. To facilitate discovery and its translation into direct benefit to people with dementia and the general public, NIA awards ADRCs to institutions that have a critical mass of excellent dementia-relevant scientific research and share the resulting research resources widely in order to have the greatest impact.

Core Components

 

Alzheimer’s Centers are required to include the following six cores and one component:

• Administrative: Manage and coordinate interactions among the Director, the core leaders, the principal investigators of research projects using the cores, other researchers at the applicant institution as well as outside institutions, appropriate institutional administrative personnel, the staff of the awarding agency, and the members of the community in which the Center is located. Administer development project grant program.
• Clinical: Establish and maintain a clinical enterprise that provides valuable, well-documented resources for cutting-edge clinical research for both Center personnel and the wider scientific community.
• Data Management and Statistical (DMS): Provide data management support and statistical consultation to facilitate research and sharing of other cores and research projects utilizing resources of the ADRC. Facilitate both local analyses as well as collaborations between and among Centers and with NACC and the broader research community.
• Neuropathology: Provide post-mortem diagnosis on all participants enrolled in the clinical core and on other well-documented AD cases and controls that may contribute to knowledge about dementia. Manage the biospecimen collection of the Center and coordinate catalogs with NACC.
• Outreach, Recruitment, and Engagement (ORE): Provide important liaison and engagement between the ADRC and people with dementia, their caregivers, and both the professional and local lay community so that information may be communicated bi-directionally, particularly in diverse populations. Augment participant and community engagement.
• Biomarker: Collect, store, track, share, and analyze biomarkers (fluid, image, wearable, etc.). May be standard or novel biomarkers. Should contribute to understanding of heterogeneity, onset, or progression of disease symptoms and/or improved diagnosis. Catalogs of available biomarkers and relevant data should be shared with NACC, and samples may be shared through NCRAD.
• Research Education Component (REC): Support research educational activities to support a workforce to meet the nation’s research needs in AD/ADRD. This should include increasing expertise and developing the next generation of scientists who will be effective in leading cross-disciplinary, translational, team-science projects on AD or AD-related dementias. The Research Education Component will be supported through an RL5 award linked to the P30 Center Core Grant.

Centers are expected to propose additional cores which contribute to the overall focus of the Center, are scientifically justified, develop resources that support other research affiliated with the Center, and fit within the budget guidelines outlined in Section II. Award Information of the FOA. Additional cores are expected to be innovative and to serve the needs, not only of the local research community, but ideally also the national and international research communities. These cores may be unique to an individual Center or they may collaborate with other similar cores at ADRCs across the country.

 

Additional Information

Full Solicitation: https://grants.nih.gov/grants/guide/rfa-files/RFA-AG-21-019.html

 

For additional information, please contact the Limited Submissions Team with questions at Limited_Submissions@unc.edu.

 

 

Limited Submissions Team

Office of Research Development

University of North Carolina at Chapel Hill

308 Bynum Hall

Chapel Hill, NC 27599

(919) 962-7503