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Since my initial involvement in the discovery of oncogenic RAS genes in human cancer in 1982, my research has focused on defining the mechanisms by which RAS oncoproteins drive cancer growth. Overall, our studies take a multi-faceted approach that includes the application of protein crystallography, transcriptome analyses, kinome profiling and proteomics/phosphoproteomics, chemical and genetic screenings, and the use of genetically-engineered mouse or patient-derived organoid models of pancreatic, colon and gastric cancer. Our studies address basic mechanisms of signal transduction and we work closely with the biotech and pharmaceutical industry to help transition novel targeted therapies for cancer into the clinic.
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CLINICAL/RESEARCH INTERESTS:
Cancer Biology, Cell Signaling, Clinical Trials, Computational Biology, Drug Discovery, Gastrointestinal Biology, Metabolism, Translational Medicine |