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The Jiang Lab, situated within the UNC HIV Cure Center and BCBP, is dedicated to unraveling the molecular mechanisms governing stable HIV reservoirs within the immune cells of people with HIV (PWH) undergoing antiretroviral therapy (ART). Our primary focus lies in comprehending the regulation of HIV transcription machinery during both active HIV transcription and latency phases.
Our investigations encompass a spectrum of in vitro, ex vivo, and in vivo models of HIV infection and latency. These include studies utilizing HIV-infected humanized mouse models, SIV-infected rhesus macaques, and observations from PWH undergoing ART. We are keenly interested in exploring the mechanisms contributing to stable HIV reservoirs, spanning peripheral compartments such as PBMCs, spleen, liver, and the central nervous system, notably the brain.
To address the complex questions surrounding HIV cure, we employ a combination of traditional biochemical, molecular biological, and virological approaches, alongside cutting-edge omics analyses. We aim to translate our insights into therapeutic interventions to eradicate HIV persistence.
Also, the Jiang Lab actively investigates the pathogenesis of other viruses, including HTLV and human endogenous retroviruses (HERVs). We enthusiastically welcome collaborations with scientists within UNC and beyond.