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The vast majority of the RNA produced by the cell does not encode protein. My research aims to uncover the mechanisms by which noncoding RNA can regulate epigenetic, transcriptional, and post-transcriptional layers of gene expression in health and disease. My research uses a combination of molecular biology, biochemistry, genetics, and genomics to interrogate fundamental mechanisms in RNA biology. Much of my work focuses on delineating functional mechanisms of model long noncoding RNAs such as Xist, which orchestrates the essential process of X-chromosome inactivation in female cells of placental mammals. I am particularly interested in understanding how RNA-protein interactions elicit noncoding RNA function, and my work advances the ways such interactions can be studied.
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CLINICAL/RESEARCH INTERESTS:
Biochemistry, Bioinformatics, Cancer Biology, Cell Biology, Computational Biology, Epigenetics and Chromatin Biology, Evolutionary Biology, Genetics, Genomics, Molecular Biology, Other, Stem Cells |