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Our long-term aspiration is to understand how the human cell cycle is organized for proliferation control and genome maintenance. Among the principal goals in this endeavor are determining molecular mechanisms and regulatory networks that establish and maintain cell cycle quiescence and defining pathways that govern the G1/S phase transition. We are particularly interested in how signaling ensures precise and complete genome duplication in normal cells and how this regulation is corrupted in cancer cells. We also explore the molecular changes in cancer and normal cells responding to or escaping from targeted cancer treatments. We use combinations of molecular biology, biochemistry, cell biology, and quantitative imaging of both fixed and live cells.
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UNC AFFILIATIONS:
Biochemistry & Biophysics, Lineberger Cancer Center, Pharmacology |
CLINICAL/RESEARCH INTERESTS:
Biochemistry, Cancer Biology, Cell Biology, Microscopy, Molecular Biology, Pharmacology |