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Our cardiovascular research laboratory studies the glycobiology (glycoprotein- and/or glycolipid-dependent biologic processes) inherent to the pathogenesis of inflammatory vascular and blood disease processes. We are particularly interested in understanding the glycobiology of the leukocyte adhesion cascade as a critical early component of inflammatory and immune-mediated processes, including atherosclerosis. Our work in this area focuses on understanding how the selectin-type adhesion molecules and their glycoprotein receptors contribute to the recruitment of various leukocyte types at the sites necessary for atherosclerotic disease development and progression. Particular attention is directed toward understanding the role of two enzymes, alpha(1,3)-fucosyltransferase IV and VII, in the synthesis of active selectin adhesion molecule ligands used for leukocyte homing and trafficking in vascular disease. We are also interested in understanding the glycobiology of thombosis and hemostasis, particularly the underlying mechanisms by which fucosyltransferase activity modulates the susceptibility to thrombosis.
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CLINICAL/RESEARCH INTERESTS:
Biomedical Engineering, Cardiovascular Biology, Cardiovascular disease, Cell Biology, Immunology, Medical Education, Microscopy, Molecular Biology, Other, Pathology, Systems Biology, Translational Medicine |