Kevin A. Friede, MD

EMAIL: kevin.friede@unc.edu

PERSONAL WEBSITE: https://www.med.unc.edu/medicine/directory/kevin-a-friede-md/

PUBLICATIONS:

I am an interventional cardiologist and physician-scientist with a research focus on developing strategies using pharmacogenomic data to mitigate ischemic and bleeding risk in patients with cardiovascular disease, especially coronary artery disease (CAD). For the last several years, I have been studying gene expression signatures of antiplatelet and anticoagulant drug exposure. By leveraging data from drug challenge studies and large trial biorepositories, we have shown that these signatures are biomarkers of ischemic and bleeding risk in patients with CAD. Choosing the correct drug, dose, and duration of therapy for patients taking antiplatelet and anticoagulant drugs for CAD is a major emphasis of recent clinical and translational investigations. We believe that adding gene expression assessment to the current approach, which employs clinical variables and single-gene polymorphism data, can be a strategy for dynamic and truly personalized optimization of effectiveness and risk for patients taking such drugs. My long-term goal is to use these approaches to help guide clinicians prescribing antiplatelet and anticoagulant agents for the first time as well as adjusting therapy over time.