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I leverage novel mouse models toward the elucidation of pathophysiological mechanisms underlying neurodevelopmental disorders, with the ultimate goal of developing efficacious gene therapies. Currently, I am preclinically testing a gene transfer therapy for Angelman syndrome and exploring opportunities to treat Dup15q syndrome with UBE3A-targeting antisense oligonucleotides.

UNC AFFILIATIONS:

Cell Biology & Physiology, Neuroscience Center

CLINICAL/RESEARCH INTERESTS:

Autism, Developmental Biology, Genetics, Neurobiology, Translational Medicine