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My laboratory provides a unique perspective on the contribution of coagulation and fibrinolytic factors to a wide spectrum of disease pathologies, through pathways both dependent and independent of their traditional roles in bleeding and thrombosis. We utilize mouse models to analyze specific mechanisms by which proteins such as prothrombin, fibrinogen, and plasminogen contribute to the progression of inflammatory, infectious, and malignant disease. Working with our collaborative basic science and clinical partners in the Blood Research Center, Lineberger Cancer Center, and various Departments across the UNC School of Medicine provides an unparalleled opportunity for rapidly advancing our understanding of the multifaceted role of the hemostatic system in hemostasis, thrombosis, and beyond.


UNC AFFILIATIONS:

Blood Research Center, Lineberger Cancer Center, McAllister Heart Institute, Pathology & Lab Medicine

CLINICAL/RESEARCH INTERESTS:

Bacteriology, Cancer Biology, Cardiovascular disease, Diabetes, Hematology, Immunology, Molecular Biology, Pathogenesis & Infection, Pulmonary, Translational Medicine