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Our group uses the tools of molecular biology to study HIV pathogenesis and latency. We have specific interests in how the virus evolves to infect a new cell type, usually in the brain, to cause a distinct form of pathogenesis. Our interests include the evolution of drug resistance to protease inhibitors, and the steps of assembly/virion maturation and RNA expression/splicing in viral replication. We also have a special interest in determining when replicating virus enters the latent reservoir. We have used UMIs in our deep sequencing protocols to identify recent infections in the public health setting, and to define the mechanism of action of mutagenic nucleosides for inhibition of several RNA viruses.
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UNC AFFILIATIONS:
Biochemistry & Biophysics, Center for AIDS Research (CFAR), Institute for Global Health & Infectious Disease, Lineberger Cancer Center, Microbiology & Immunology, Virology |
CLINICAL/RESEARCH INTERESTS:
Drug Discovery, Evolutionary Biology, Genetics, Genomics, HIV/AIDS, Microbiology, Molecular Biology, Pathogenesis & Infection, Virology |