Dr. Chang’s current research projects focus on the developments of advanced functional MRI (fMRI) and diffusion MRI (dMRI) with ultrahigh resolution, ultrashort scan time, and improved robustness. The high-resolution fMRI was developed to study the brain-wide functional networks of hippocampal subfields as potential AD biomarker. This project has received funding support from NIH R21 grant in 2019. He also developed novel approaches to break the current limits of submillimeter-resolution dMRI. In addition to the extraordinary imaging performance, Dr. Chang commits to translate the techniques from bench to bedside. To improve the clinical applicability, he dedicates on improving the robustness against common imaging corruptions by motion, noise, and field inhomogeneity.
