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The Polacheck Lab develops microfluidic and organ-on-chip technology for disease modeling and regenerative medicine with a focus on the blood vascular and vascular endothelial cell biology. Our efforts are organized around three primary research thrusts: 1) Developing humanized microphysiological models for inherited and genetic disorders; 2) Defining the role of biofluid mechanics and hemodynamics on the cellular microenvironment; 3) Understanding the role of cell-cell adhesion in the generation and propagation of cellular forces during morphogenesis. We further work to translate the technology and techniques developed in our lab into tissue engineered therapies for organ replacement and regenerative medicine.
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UNC AFFILIATIONS:
Biomedical Engineering, Cell Biology & Physiology, Kidney Center, McAllister Heart Institute |
CLINICAL/RESEARCH INTERESTS:
Biomaterials, Biomechanics, Biomedical Engineering, Cardiovascular Biology, Cardiovascular disease, Cell Biology, Cell Signaling, Regenerative Medicine |