Skip to main content

Overview:

The Calabrese laboratory is recruiting motivated individuals interested in studying mechanisms of genome regulation by long noncoding RNAs. Projects in the lab currently focus on understanding mechanisms of RNA-mediated gene silencing and recruitment of Polycomb complexes to chromatin, and developing methods to predict relationships between lncRNA sequence and function. The lab uses a combination of genomics, genetics, molecular and cell biology, biochemistry, and computational biology to achieve its research objectives. Experimental, computational, and hybrid projects are available. A long-term goal of ours is to be able to predict and rationally-design the regulatory functions of lncRNAs from analysis of their sequence content alone; recent advances in experimentation and computation, particularly in the field of natural language processing, have placed these advances within reach. We seek to employ motivated individuals from all backgrounds and levels of expertise who are passionate about biology or computer science.