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Understanding Brain Functional Dynamics Through Neural Koopman Operator with Control Mechanism

July 22, 2025
We developed an explainable deep learning model that uses brain imaging data to uncover how cognitive states emerge from complex brain dynamics. By modeling the brain as a controllable system, our approach offers new insights into how brain function supports behavior.

Prepronociceptin-expressing neurons in the bed nucleus of the stria terminalis signal escape behavior

July 22, 2025
These results highlight a novel role of a unique set of neurons within a brain region known as the extended amygdala that signal escape behavior in response to an aversive stimulus. This, in combination with our previous findings that these same neurons encode arousal responses, supports a neurobiological relationship of...

Different Tools, Different Results: Comparing Methods for Bullying Assessment in Autistic and ADHD Youth

July 22, 2025
This study compared three tools for assessing bullying in autistic and ADHD youth and found variable patterns of prevalence and vulnerability between approaches. A disability-specific measure identified more nuanced patterns of victimization, underscoring the importance of using tailored and valid assessments in these populations.

Comparative cardiac safety of haloperidol vs. chlorpromazine among people receiving hemodialysis

July 22, 2025
Sudden cardiac death is >20 times more likely among individuals receiving maintenance hemodialysis, relative to individuals not receiving hemodialysis. We compared the comparative cardiac safety associated with typical antipsychotics among individuals receiving hemodialysis.

Electroconvulsive Therapy in a Left Ventricular Assist Device Recipient With Treatment-Resistant Depression

July 22, 2025
We present a case of a left ventricular assist devices recipient with treatment-resistant depression who was successfully treated with electroconvulsive therapy. Our case describes an approach by which electroconvulsive therapy can be safely delivered to left ventricular assist device recipients with a collaborative multidisciplinary team approach.

Comparative child mental health and academic outcomes after primary school teachers deliver task-shifted mental health care in India

July 22, 2025
Our study demonstrates that training teachers in “education as mental health therapy” (Ed-MH) novel approach integrating psychological principles into everyday classroom management significantly improves children’s mental health and academic performance. The large effects we observed, similar in magnitude to medication or traditional therapy, highlight the potential of Ed-MH to bring...

Resilience and strengths in the Black autism community in the United States: A scoping review

July 22, 2025
Gaps in research knowledge pertaining to resiliency factors and strengths among the Black autism community, inclusive of autistic persons and their support system exist. A scoping review was conducted to further explore quantitative, qualitative, and mixed methods studies that investigate resiliency factors and related strengths in the Black autism community...

A Consensus Taxonomy of Altered (Nonordinary) States of Consciousness: Bringing Order to Disarray

July 22, 2025
A multi-disciplinary, international consensus of a taxonomy (classification system) for altered states of consciousness.

Depressive and Anxiety Symptoms During Chemotherapy for Breast Cancer and the Potential Impact of Pre-Treatment Health Behaviors

July 22, 2025
In this study of 330 breast cancer patients, at least moderately severe depressive and anxiety symptoms were reported by 27% and 38%, respectively, and most prevalent during the first 3 weeks of chemotherapy. Patients who smoke may be at particularly elevated risk for worse mental health outcomes.

Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity

July 22, 2025
Developmental trauma (DT) and poorer episodic memory performance are associated with increased risk of psychotic symptoms, but the mechanisms underlying these associations remain to be established. We sought to investigate whether memory performance and fMRI activity during the retrieval phase of an associative episodic memory task statistically mediated the relationship...