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This study shows evidence that temporally resolved and functionally contextualized structural basis sets can accurately reflect dynamic functional processes and capture diagnostically relevant structure-functional coupling while detecting nuanced functionally driven structural components that cannot be captured with traditionally computed structural bases. Differential analysis of component stability across repeated scans from...

This study suggest that reduced pyramidal cell excitability is present at baseline in future CHR-Converters, supporting the hypothesis that hypofunction of pyramidal cells is a primary pathology in schizophrenia, rather than a consequence of chronic illness. Positive symptoms among CHR-Converters may reflect compensatory downregulation of inhibition.

This study reveals small but consistent associations between negative symptom dimensions and predominantly prefrontal region cortical thickness, and limbic region volumes. These findings advance our understanding of the network of anatomical regions that may contribute to the severity of negative symptoms in schizophrenia.

Children as young as 5 years old may experience thoughts about suicide, but these behaviors are not well understood. This study involved 98 children 5 to 10 years of age, recruited for potential adversity exposure, and their caregivers, who answered questions about suicidal thoughts and behaviors (STBs) during an in-home...

About 1 in 5 women experience depression at some point during pregnancy and in the year after giving birth, known as perinatal mood and anxiety disorder (PMAD). Antidepressant use during pregnancy isn’t a question of “safe versus unsafe,” but about balancing the risks of untreated depression with the risks of...

This award provides transition funding at the end of her postdoctoral training to support the move into a tenure-track faculty position and includes a $600,000 three-year faculty research grant. Melissa Walsh, Ph.D., is currently a research trainee in the Department of Psychiatry at the University of North Carolina at Chapel...