Peadar Noone

Peadar Noone

Degrees 

MB, Bch BAO:
(1983) U. College Galway Medical School, Ireland

MD [Doctorate Degree]:
(1997) U. College Galway Medical School, Ireland

Residency/Fellowship:
(1983-89) Univ. Hospital in Galway & Dublin, Ireland Tufts University, Boston, MA
UNC, Chapel Hill, NC

Academic & Professional Titles:
Associate Professor of Medicine
Medical Director, Lung Transplant Program

Phone: 919-966-2531
Email: pnoone@med.unc.edu

Clinical Interests:

  1. Lung Transplant Medicine
  2. General internal medicine & General Pulmonary Medicine
  3. Lung diseases associated with genetic abnormalities – cystic fibrosis, primary ciliary dyskinesia, bronchiectasis.
  4. Infectious diseases of the lung – tuberculosis and non-tuberculous infections

Research Interests:

The correlations between genetic disease and disease expression at a cell biologic and organ level, particularly as pertains to airways disease and other related diseases.

  1. Airway host defence, disorders of ciliary structure/function.
  2. Drug delivery to the lung.
  3. Gene therapy, and other novel therapies for CF.
  4. Genetics of airways diseases.

Recent Publications:

Refereed Papers (Selected 2001 - Present):

  1. PG. Noone*, M Zariwala*, A Sannuti, S Minnix, Z Zhou, MW Leigh, M Hazucha, JL Carson, MR Knowles. Germline Mutations in DNAI1 (IC78) Cause Primary Ciliary Dyskinesia. Am J Resp Cell Mol Biol 2001;25:577-583. (* Co-first authors).
  2. PG Noone, MR Knowles. “CFTR-opathies”: Disease phenotypes associated with CFTR gene mutations. Respiratory Research 2001, 2: 328-332.
  3. Olbrich H, Haffner K, Kispert A, Volkel A, Volz A, Sasmaz G, Lehrach H, Konietzko N, Zariwala M, Noone PG, Knowles MR, Mitchison H, Chung E, Hildebrandt F, Sudbrak R, Omran H. Mutations of DNAH5 cause primary ciliary dyskinesia and randomization of left-right asymmetry. Nature Genetics 2002; 30:143-144.
  4. Noone PG, Zariwala M, Sannuti A, Minnix S, Leigh MW, Carson J et al. Mutations in DNAI1 (IC78) Cause Primary Ciliary Dyskinesia. Chest 2002; 121(3 Suppl):97S-98S.
  5. A Kispert, H Olbrich, A Volz, U-P Ketelsen, J Horvath, R Melkaoui, M Petry, M Zariwala, PG Noone, MR Knowles, and H Omran. Evidence for Genotype-Phenotype Correlations in DNAH5 Mutations of Patients with Primary Ciliary Dyskinesia - Expression of DNAH5’s Mouse Ortholog in the Upper and Lower Airway. Thorax. 2003 Jun;58(6):552-4.
  6. PG Noone; MW Leigh; A Sannuti; SL Minnix; JL Carson; M Hazucha; M Zariwala; MR Knowles. Primary ciliary dyskinesia: Diagnostic and phenotypic features. Am J Respir Crit Care Med. 2004 Feb 15;169(4):459-67.
  7. Zariwala M, O'Neal WK, Noone PG, Leigh MW, Knowles MR, Ostrowski LE. Investigation of the possible role of a novel gene, DPCD, in Primary Ciliary Dyskinesia. Am J Respir Cell Mol Biol. 2004 Apr;30(4):428-34.
  8. Standert, TA, Boitano L, Emerson J, Milgram LJ, Konstan MW, Hunter J, Berclaz PY, Brass L, Zeitlin PL, Hammond K, Davies Z, Foy G, Noone PG, Knowles MR. Standardized procedure for measurement of nasal potential difference: an outcome measure in multicenter cystic fibrosis clinical trials. Pediatr Pulmonol. 2004 May;37(5):385-92.
  9. Noone PG, Southern, KW. Unravelling salt transport in cystic fibrosis. Thorax. 2004 Nov;59(11):916-7.
  10. Chmura K, Chan ED, Noone PG, Zariwala M, Winn RA, Knowles MR, Iseman MD, Gardner EM. A middle-aged woman with recurrent respiratory infections. Respiration. 2005 Jul-Aug;72(4):427-30.
  11. Macartney C, Burke E, Elborn S, Magee N, Noone PG, Gleadhill I, Allen D, Kettle P, Drake M.
    Department of Haematology. Bronchiolitis obliterans organizing pneumonia in a patient with non-Hodgkin's lymphoma following R-CHOP and pegylated filgrastim. Leuk Lymphoma. 2005 Oct;46(10):1523-6.
  12. Hornef N, Olbrich H, Horvath J, Zariwala MA, Fliegauf M, Loges NT, Wildhaber J, Noone PG, Kennedy M, Antonarakis SE, Blouin JL, Bartoloni L, Nublein T, Ahrens P, Griese M, Kuhl H, Sudbrak R, Knowles MR, Reinhardt R, Omran H. DNAH5 Mutations are a Common Cause of Primary Ciliary Dyskinesia with Outer Dynein Arm Defects. Am J Respir Crit Care Med. 2006 Jul 15;174(2):120-6. Epub 2006 Apr 20.
  13. Burrows E, Southern K, Noone PG. Sodium channel blockers for cystic fibrosis. Cochrane Database Syst Rev. 2006 Jul 19;3:CD005087.
  14. Kennedy, M. P., P. G. Noone, J. Carson, P. L. Molina, A. Ghio, M. A. Zariwala, S. L. Minnix, and M. R. Knowles. 2007. Calcium stone lithoptysis in primary ciliary dyskinesia. Respir Med 101:76-83.
  15. Zariwala MA, Leigh MW, Ceppa F, Kennedy MP, Noone PG, et. al. Mutations of DNAIl in primary ciliary dyskinesia: Evidence of founder effect in a common mutation. Am J Respir Crit Care Med. 2006; 174: 858-866.
  16. Kennedy MP, Omran H, Leigh MW, Dell S, Morgan L, Zariwala MA, Molina PL, Minnix SL, Severin T, Ahrens P, Lange L, Noone PG, Knowles MR. Congenital heart disease and other heterotaxic defects in a large cohort of patients with primary ciliary dyskinesia. Circulation. 2007 Jun 5;115(22):2814-21.
  17. Kennedy MP,Noone PG,Leigh MW, Zariwala MA, Minnix SL, Knowles MR, Molina PL. High-Resolution CT of Patients with Primary Ciliary Dyskinesia. Am J Roentgenol. 2007 May;188(5):1232-8.
  18. Kennedy, M. P., P. G. Noone, J. Carson, P. L. Molina, A. Ghio, M. A. Zariwala, S. L. Minnix, and M. R. Knowles. 2007. Calcium stone lithoptysis in primary ciliary dyskinesia. Respir Med 101:76-83.

Contributions to Textbooks (Selected 2006 - Present):

  1. Section editor: Pulmonary Diseases section, Noone PG and Boucher RC: Principles of Molecular Medicine, Runge and Patterons Eds. 2006 Humana Press, Totowa, New Jersy.
  2. Noone, P. G., Zariwala, M., and Knowles, M. R. (2006). Primary ciliary dyskinesia, in Principles of Molecular Medicine, 2nd ed., (Runge, M. S. and Patterson, C., eds.), Humana Press, Totowa, NJ, pp. 239-250.

Letters/Short Articles:

  1. Noone PG, Egan TM. Cystic fibrosis lung disease – when to refer for lung transplantation; is the answer clear. Am J Resp Crit Care Med. 2002; 166:1531-2.
  2. Kispert A, Petry M, Olbrich H, Volz A, Ketelsen UP, Horvath J, Melkaoui R, Omran H, Zariwala M, Noone PG, Knowles M.Genotype-phenotype correlations in PCD patients carrying DNAH5 mutations. Thorax. 2003 Jun;58(6):552-4.
  3. Noone PG, Southern KW. Unraveling salt transport in cystic fibrosis. Thorax 2004; 59:916-7.
  4. Kennedy MP, Noone PG and Michael R Knowles MR. Airway Calcium Deposition and Broncholithiasis in Disorders of Mucociliary Clearance. Arch Bronconeumol. 2007 Aug;43(8):474. English, Spanish. PMID: 17692252
  5. PG Noone. Non-invasive ventilation to treat hypercapnic respiratory failure in cystic fibrosis. Thorax, 2008; 63: 5-7.