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Male sex, ostomy, infection, and intravenous fluids are associated with increased risk of postoperative ileus in elective colorectal surgery

December 13, 2021

Surgery Author: Muneera R. Kapadia, MD | Surgery Journal

Postoperative ileus is a common and costly complication after elective colorectal surgery. Effects of intravenous fluid administration remain controversial, and the effect of ostomy construction has not been fully evaluated. Various restrictive intravenous fluid protocols may adversely affect renal function. We aimed to investigate the impact of intestinal reconstruction and intravenous fluid on ileus and renal function after colorectal resection under an enhanced recovery protocol.

Socioeconomic factors in timing of esophagectomy and association with outcomes

December 13, 2021

Residency Author: Kevin A. Chen, MD | Faculty Author: Michael O Meyers | Journal of Surgical Oncology

Disparities in esophageal cancer are well-established. The standard treatment for locally advanced esophageal cancer is chemoradiation followed by surgery. We sought to evaluate the association between socioeconomic factors, time to surgery, and patient outcomes.

Pulmonary complications observed in patients with infective endocarditis with and without injection drug use: An analysis of the National Inpatient Sample

December 13, 2021

Authors: Gita N. Mody, MD, John S. Ikonomidis, MD, Jason M. Long | Journal: PLoS One

The impact of cardiovascular and neurologic complications on infective endocarditis (IE) are well studied, yet the prevalence and significance of pulmonary complications in IE is not defined. To better characterize the multifaceted nature of IE management, we aimed to describe the occurrence and significance of pulmonary complications in IE, including among persons with IE related to drug use.

Pathology and Molecular Characteristics of Pancreatic Cancer

December 13, 2021

Residency Author: Joseph F Kearney, MD | Faculty Author: Jen Jen Yeh, MD | Journal: Surgical Oncology Clinics of North America

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. However, it should be kept in mind that there are other pancreatic cancers that are classified by their cellular lineage: acinar cell carcinomas (acinar differentiation), neuroendocrine neoplasms (arising from the islets), solid-pseudopapillary neoplasms (showing no discernible cell lineage), and pancreatoblastomas (characterized by multiphenotypic differentiation, including acinar endocrine and ductal). This article focuses on the molecular and pathology alterations in PDAC.

Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators

December 13, 2021

Leader Author: Robert Maile, PhD | International Journal of Molecular Sciences

Severe burn injury is a devastating form of trauma that results in persistent immune dysfunction with associated morbidity and mortality. The underlying drivers of this immune dysfunction remain elusive, and there are no prognostic markers to identify at-risk patients.

Causes of death following discharge after trauma in North Carolina

December 13, 2021

Residency Author: Mary K Bryant, MD | Faculty Authors: Sharon Schiro, PhD, Lauren Raff, MD, Arielle J. Perez, MD, Trista Reid, MD | The Journal of Trauma and Acute Care Surgery

While a “fourth peak” of delayed trauma mortality has been described, limited data describe the causes of death (COD) for patients in the years following an injury. This study investigates the difference in COD statewide for patients with and without a recent trauma admission.