This novel, randomized clinical trial will evaluate if vitamin K supplementation impacts pain and function in patients with knee OA who are vitamin K insufficient.
The innovative research seeks to identify putative causal knee OA risk variants, map them to their target genes, and quantify their phenotypic impact in chondrocytes.
The research showed early deletion of Ccr2 in aggrecan-expressing cells reduces the initiation, but not the progression, of post traumatic osteoarthritis and its associated pain.
Read about TARC’s Strategic Planning Retreat, get an update from our Director, and learn about TARC grants, our upcoming Research Day and seminars, the key offerings of our CCCR, as well as spotlights/kudos for our team members.
Members of the Thurston Arthritis Research Center (TARC) and their families recently braved the heat to “walk the walk” at the 2020 AF event, held in Raleigh, N.C.
This award includes support for him to attend the 2022 ACR Convergence Meeting in Philadelphia, where he will present his abstract, “Redoxosomes Mediate a Feed-forward Loop of Cartilage Matrix Destruction Through α5β1 Integrin Signaling in Response to a Fibronectin Matrikine”.
The 5-year, K24 award from NIH/NIAMS will leverage Dr. Nelson’s ongoing POR program, enhance her professional development and that of her trainees, and support her mentoring early stage investigators.
The aim of this 1-year award is to advance equity in lupus clinical trials by identifying, synthesizing, and disseminating innovative approaches and best practices to advance participant diversity in lupus clinical trials.
This research helps address an urgent need to understand the factors that promote progression and worsening of multi-joint osteoarthritis (MJOA), a common but understudied, progressive disease.
Dr. Sheikh was the UNC Principal Investigator for this study, which was conducted at UNC’s Clinical & Translational Research Center (CTRC), a resource through NC TraCS.