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The grant is a 5-year renewal of existing research funded by the National Institute of Aging.

The overall goal of the research project is to understand the mechanisms by which oxidative stress governs development and maintenance of the senescence-associated secretory phenotype in articular joints.

Dr. Loeser is Director of the UNC Thurston Arthritis Research Center, and is the Joseph P. Archie, Jr. Eminent Professor of Medicine in the Division of Rheumatology, Allergy and Immunology.