Key Papers (newest first)

Law, J. A., Du, J., Hale, C. J., Feng, S., Krajewski, K., Strahl, B. D., Patel, D. J. & Jacobsen, S. E. (2013) SHH1 recruits RNA Polymerase-IV to RNA-directed DNA methylation targets. Nature. doi: 10.1038/nature12178

Cai, L., Rothbart, S. B., Lu, R., Xu, B., Tripathy, A., Chen, W.-Y., Zheng, D., Patel, D. J., Allis, C. D., Strahl, B. D., Song, J., Wang, G. G. (2013) An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Molecular Cell. 49:571-582

Ali, M., Yan, K., Lalonde, M.-E., Degerny, C., Rothbart, S. B., Strahl, B. D., Cote, J., Yang, X-.J. & Kutateladze, T., G. Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin. J. Mol. Biol. 328-288

Nishikori, S., Fuchs, S. M., Yasui, N., Wojcik, J., Koide, A., Strahl, B. D., Koide, S. A quantitative and sensitive method for characterizing anti-histone antibodies. J. Mol. Biol. 424:391-399

Rothbart SB, Krajewski K, Nady N, Tempel W, Xue S, Badeaux AI, Barsyty-Lovejoy D, Martinez JY, Bedford MT, Fuchs SM, Arrowsmith CH, Strahl BD. (2012) Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol. 19:1155-60

Rizzardi LF, Dorn EE, Strahl BD, Cook JG (2012) H3K4 di-methylation promotes DNA replication origin function in Saccharomyces cerevisiae. Genetics 192:371-384

Rothbart SB, Krajewski K, Strahl BD, Fuchs SM. (2012) Peptide microarrays to interrogate the histone code. Methods Enzymol. 512:107-135

Rothbart SB, Lin, S, Britton, L-M, Krajewski K., Keogh M-C., Garcia, Strahl BD. (2012) Poly-acetylated chromatin signatures are preferred epitopes for site-specific histone H4 acetyl antibodies. Scientific Reports. 2:489

Stolzenburg S, Rots MG, Beltran AS, Rivenbark AG, Yuan X, Strahl BD, Blancafort P. (2012) Targeted silencing of the oncogene transcription factor SOX2 in breast cancer. In press at Nucleic Acid Research. 40, 6725-6740

Rivenbark AG, Stolzenburg S, Yuan X, Strahl BD, Blancafort P. (2012) Epigenetic reprogramming of cancer cells by targeted DNA methylation. Epigenetics. 7, 1-11

Fuchs SM, Kizer KO, Braberg H, Krogan N, Strahl BD. (2012) RNA polymerase II CTD phosphorylation regulates protein stability of the Set2 methyltransferase and histone H3 di- and trimethylation at lysine 36. J Biol Chem. 287, 3249-3256

Fuchs SM, Krajewski K, Miller V, Baker RW, Strahl BD. (2011) Influence of combinatorial histone modifications on antibody and effector protein recognition. Current Bio. 11, 53-58

Gardner KE, Zhou L, Parra MA, Chen X, Strahl BD. (2011) Identification of lysine 37 of histone H2B as a novel site of methylation. PLoS ONE. 6:e16244

Ramachandran S, Vogel L, Strahl BD, Dokholyan NV. (2011) Thermodynamic stability of protein-protein interaction is a necessary but not sufficient driving force for evolutionary concervation. PLoS Comput Biol. 7:e1001042

Nakanishi S, Lee JS, Gardner KE, Gardner JM, Takahashi Y-H, Chandrasekharan MB, Sun Z-W, Osley MA, Strahl BD, Jaspersen SL, Shilatifard A. (2009) Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. J of Cell Bio. 186, 371-377

Lickwar C, Rao B, Shabalin A, Nobel A, Strahl BD, Lieb JD. (2009) The Set2/Rpd3S pathway suppresses cryptic transcription without regard to gene length or transcription frequency PLoS ONE. 4:e4886

Youdell ML, Kizer KO, Kisseleva-Romanova E, Fuchs SM, Duro E, Strahl BD, Mellor J. (2008) Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36. Mol. Cell. Biol. 28, 4915-26

Merker JD, Dominska M, Greenwell PW, Rinella E, Bouck DC, Shibata Y, Strahl BD, Mieczkowski P, Petes TD. (2008) The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. DNA Repair (Amst) 7, 1298-308

Wyce A, Xiao T, Whelan KA, Kosman C, Walter W, Eick D, Hughes TR, Krogan NJ, Strahl BD, Berger SL. (2007) H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Mol. Cell 27, 275-88

Laribee RN, Shibata Y, Mersman DP, Collins SR, Kemmeren P, Roguev A, Weissman JS, Briggs SD, Krogan NJ, Strahl BD. (2007) CCR4/NOT complex associates with the proteasome and regulates histone methylation. Proc. Natl. Acad. Sci. USA 104, 5836-41

Garcia BA, Hake SB, Diaz RL, Kauer M, Morris SA, Recht J, Shabanowitz J, Mishra N, Strahl BD, Allis CD, Hunt DF. (2007) Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem. 282, 7641-55

Morris SA, Rao B, Garcia BA, Hake SB, Diaz RL, Shabanowitz J, Hunt DF, Allis CD, Lieb JD, Strahl BD. (2007) Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. J Biol Chem. 282, 7632-40

Xiao T, Shibata Y, Rao B, Laribee RN, O'Rourke R, Buck MJ, Greenblatt JF, Krogan NJ, Lieb JD, Strahl BD. (2007) The RNA polymerase II kinase Ctk1 regulates positioning of a 5' histone methylation boundary along genes. Mol Cell Biol. 27, 721-31

Biswas D, Dutta-Biswas R, Mitra D, Shibata Y, Strahl BD, Formosa T, Stillman DJ. (2006) Opposing roles for Set2 and yFACT in regulating TBP binding at promoters. EMBO J. 25, 4479-89

Vojnic E, Simon B, Strahl BD, Sattler M, Cramer P. (2006) Structure and carboxyl-terminal domain (CTD) binding of the Set2 SRI domain that couples histone H3 Lys36 methylation to transcription. J Biol Chem. 281, 13-5

Keogh MC, Kurdistani SK, Morris SA, Ahn SH, Podolny V, Collins SR, Schuldiner M, Chin K, Punna T, Thompson NJ, Boone C, Emili A, Weissman JS, Hughes TR, Strahl BD, Grunstein M, Greenblatt JF, Buratowski S, Krogan NJ. (2005) Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell 123, 593-605

Rao B, Shibata Y, Strahl BD, Lieb JD. (2005) Dimethylation of histone H3 at lysine 36 demarcates regulatory and nonregulatory chromatin genome-wide. Mol Cell Biol. 25, 9447-59

Laribee RN, Krogan NJ, Xiao T, Shibata Y, Hughes TR, Greenblatt JF, Strahl BD. (2005) BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex. Curr Biol. 15, 1487-93

Morris SA, Shibata Y, Noma K, Tsukamoto Y, Warren E, Temple B, Grewal SI, Strahl BD. (2005) Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe. Eukaryot Cell. 4, 1446-54

Kizer KO, Phatnani HP, Shibata Y, Hall H, Greenleaf AL, Strahl BD. (2005) A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. Mol Cell Biol. 25, 3305-16

Xiao T, Kao CF, Krogan NJ, Sun ZW, Greenblatt JF, Osley MA, Strahl BD. (2005) Histone H2B ubiquitylation is associated with elongating RNA polymerase II. Mol Cell Biol. 25, 637-51

Lee CK, Shibata Y, Rao B, Strahl BD, Lieb JD. (2004) Evidence for nucleosome depletion at active regulatory regions genome-wide. Nat Genet. 36, 900-5

Xiao T, Hall H, Kizer KO, Shibata Y, Hall MC, Borchers CH, Strahl BD. (2003) Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast. Genes Dev. 17, 654-63

Briggs SD, Xiao T, Sun ZW, Caldwell JA, Shabanowitz J, Hunt DF, Allis CD, Brian D Strahl. (2002) Gene silencing: trans-histone regulatory pathway in chromatin. Nature 418, 498

Reviews and Commentaries

Gardner KE, Allis CD, Strahl BD. (2011) OPERating ON chromatin, a colorful language where context matters. J. Mol Bio. 409, 36-46

Fuchs SM, Laribee RN, Strahl BD. (2009) Protein modifications in transcription elongation. BBA - Gene Regulatory Mechanisms. 1789:26-36.

Henikoff S, Strahl BD, Warburton PE. (2008) Epigenomics: a roadmap to chromatin. Science 322, 853

Rivenbark AG, Strahl BD. (2007) Molecular biology. Unlocking cell fate. Science 318, 403-4

Laribee RN, Fuchs SM, Strahl BD. (2007) H2B ubiquitylation in transcriptional control: a FACT-finding mission. Genes Dev. 21, 737-43

Lee DY, Teyssier C, Strahl BD, Stallcup MR. (2005) Role of protein methylation in regulation of transcription. Endocr Rev. 26, 147-70

Scott D. Briggs & Brian D. Strahl. (2002) Unraveling heterochromatin. Nat Genet. 30, 241-2

Brian D. Strahl & C. David Allis. (2000) The language of covalent histone modifications. Nature 403, 41-5

For Citation informtion on Brian Strahl's papers, follow this link to Dr. Strahl's google scholar page