- This event has passed.
Monday – FUSION: Leo Bondel, Katie Holmes, & Jake Roetcisoender
March 31, 2025 @ 12:30 pm - 1:30 pm
Leo Bondel (Zylka lab)
- Our goal is to identify guide RNAs targeting the UBE3A-ATS in human neurons, which allow for installation of a Poly(A) signal with cytosine base editors
- These edits have the potential to restore UBE3A expression, making this an attractive therapeutic strategy for Angelman Syndrome
Katie Holmes (Baldwin lab)
- White matter astrocytes maintain key astrocytic features like tiling and endfeet but their morphological characteristics are quantifiably distinct
- White matter astrocytes take longer to mature than other astrocytes
Jake Roetcisoender (O’Brien lab)
- Vascular smooth muscle cells impact nerve development in the kidney