Matt Zimmerman (Miller lab) FRb inhibits macrophage survival and suppresses anti-tumor functions in vitro FRb ablation decreases tumor growth in preliminary experiments Nicole Hondrogiannis (Deshmukh lab) Neurons are long-lived post mitotic cells Exploring if the apoptotic pathway in neurons becomes activated in response to sublethal DNA damage
Juliet King (Williams lab) Alex Powers (Cohen lab)
Ian McCabe (Yeh lab) Identifying two clinically relevant populations of CAFs in PDAC: tumor promoting (proCAF) and tumor restrictive (restCAF) These CAF subtypes are distributed spatially and may play distinct functional roles Mark Hazelbaker (Bear lab) The Arp2/3 complex is required for the turnover of clathrin plaques ACK regulates the recruitment of the Arp2/3 complex … Read more
David Rocco (Bergmeier lab) Elucidating a novel pathway for platelet activation Understanding how this pathway contributes to platelet adhesion under arterial shear stress Andrew Kennedy (Thaxton lab) ER sheet dynamics are distended in T cells in solid cancers Balancing ER sheets and tubules may protect T cells from disturbed ER dynamics in solid tumors
Kimberly Lukasik (Gupton lab) TRIM9 modulates focal adhesion dynamics to regulate cell motility in melanoma Emily Bulik-Sullivan (Randell lab) Elucidating the mechanism of ENaC activity reduction by CC-90009 This mechanism, and CC-90009’s capacity to promote ribosomal readthrough of PTC-CFTR variants is of therapeutic interest for cystic fibrosis
Gabby Bais (Giudice lab) FXR1 may regulate the translation of many cardiomyocyte-specific proteins Expression of muscle-specific splice isoforms of FXR1 may impact the contractility of the adult heart Sherry Hsu (Cohen lab) Tubulin acetylation and polyglutamylation increase early in neuronal differentiation, exhibit distinct distributions, and are important for maintaining neuronal morphology Tubulin acetylation … Read more
Henry Uchenna (Maddox lab) Capping Protein depletion accelerates furrowing and cytokinesis, likely due to increased F-actin in the contractile ring It also disrupts spindle dynamics, potentially through effects on the dynein-dynactin complex Meghan Anderman (McCauley lab) Using human intestinal organoids to model gastrointestinal (GI) pathophysiology in cystic fibrosis Assessing the general role of … Read more
Leo Bondel (Zylka lab) Our goal is to identify guide RNAs targeting the UBE3A-ATS in human neurons, which allow for installation of a Poly(A) signal with cytosine base editors These edits have the potential to restore UBE3A expression, making this an attractive therapeutic strategy for Angelman Syndrome Katie Holmes (Baldwin lab) White matter astrocytes maintain … Read more
Cocoa T. Dixon, PhD Associate Department Head, Life Sciences Wake Technical Community College Talk focus Beyond the lecture hall: shaping a career in community college teaching Faculty host Natasha Snider, PhD More about the speaker Dr. Dixon is a passionate and innovative educator deeply committed to promoting and enhancing student success in higher education. … Read more
Sergiu Pasca, MD Kenneth T. Norris, Jr. Professor, Psychiatry & Behavioral Sciences Stanford University Research focus Understanding human brain assembly and the molecular mechanisms that lead to neuropsychiatric disease using neural organoids Faculty host Grégory Scherrer, PharmD, PhD More about the speaker Trained as a physician in Romania, Dr. Sergiu Pasca, came for postdoctoral … Read more