Led by Qi Zhang, PhD, and Robert McGinty, MD, PhD, UNC-Chapel Hill scientists used cryo-electron microscopy technology to produce the first-ever high-resolution structure of the protein cGAS bound to the DNA packaging unit inside human cell nuclei, revealing how cGAS responds to foreign or damaged DNA, but not the body’s healthy DNA.
Cognitive flexibility, which refers to the brain’s ability to switch between mental processes in response to external stimuli and different task demands, seems to begin developing during the first two years of life, which is much earlier than previously thought. UNC BRIC researchers led by Weili Lin, PhD, used magnetic resonance imaging techniques to show … Continued
In a recent Chan Zuckerberg Science Initiative (CZI) newsletter, Dr. Itano was recognized for her work facilitating collaborations between researchers and computing specialists to design and disseminate efficient bioimaging pipelines at UNC and for leading more than 90 individual training sessions for new users on microscopes in the Neuroscience Microscopy Core.
The Precision Nutrition Core now offers the QuantStudio 12K Flex Real-Time PCR System—a highly flexible, comprehensive real-time PCR platform that can genotype or quantify gene expression in a customized and targeted approach. The system can accommodate OpenArray plates, TaqMan® array cards, 384-well, 96-well, and FAST 96-well plates, allowing us to select the format that is … Continued
The Department of Chemistry Mass Spectrometry Core Laboratory is excited to offer mass spectrometry based lipidomics to the UNC Community. With Method Development Grant funding from the Core Facilities Advocacy Committee (CFAC), we have developed mass spectrometry based methods for the extraction, chromatographic separation, detection and data processing of lipids from biological matrices. Our methods … Continued
The BRIC SAI Core Facility has been awarded $2M (Ian Shih, PI) from NIH Office of the Director, to purchase a 9.4T small animal MRI scanner. The system will include the most recently released console and bring in the latest high field MR technologies to UNC. Aside from the magnet, the core will also install … Continued
The Macromolecular Interactions Facility (MacInFac) recently applied for and was just awarded, a North Carolina Biotechnology Center (NCBC) innovation impact grant for a Biacore 8K, a high-throughput Surface Plasmon Resonance (SPR) -based biosensor. With its ultra-low noise level, high sensitivity and high throughput capability, it will not only replace the current aged instrumentation in the … Continued
The Office of Research Technologies (ORT) makes available mini grants for professional development and other educational activities for core facility staff. One of our recent awardees, Bentley R. Midkiff (Translational Pathology Lab) recently completed the NSH Digital Pathology Certificate program, a self-paced course to increase knowledge and improve competency in digital pathology/whole slide imaging. “Although … Continued