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The faculty of the Department of Genetics published 11 papers during the first three weeks of 2017.

BK Polyomavirus Genomic Integration and Large T Antigen Expression: Evolving Paradigms in Human Oncogenesis.

Kenan DJ, Mieczkowski PA, Latulippe E, Côté I, Singh HK, Nickeleit V.
Am J Transplant. 2016 Dec 31. doi: 10.1111/ajt.14191. [Epub ahead of print] PMID: 28039910

Immunophenotyping and Transcriptomic Outcomes in PDX-derived TNBC Tissue.

Snowden E, Porter W, Hahn F, Ferguson M, Tong F, Parker JS, Middlebrook A, Ghanekar S, Dillmore WS, Blaesius R.
Mol Cancer Res. 2016 Dec 30. pii: molcanres.0286.2016. doi: 10.1158/1541-7786.MCR-16-0286-T. [Epub ahead of print] PMID: 28039356

A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

Noordam R, Sitlani CM, Avery CL, Stewart JD, Gogarten SM, Wiggins KL, Trompet S, Warren HR, Sun F, Evans DS, Li X, Li J, Smith AV, Bis JC, Brody JA, Busch EL, Caulfield MJ, Chen YI, Cummings SR, Cupples LA, Duan Q, Franco OH, Méndez-Giráldez R, Harris TB, Heckbert SR, van Heemst D, Hofman A, Floyd JS, Kors JA, Launer LJ, Li Y, Li-Gao R, Lange LA, Lin HJ, de Mutsert R, Napier MD, Newton-Cheh C, Poulter N, Reiner AP, Rice KM, Roach J, Rodriguez CJ, Rosendaal FR, Sattar N, Sever P, Seyerle AA, Slagboom PE, Soliman EZ, Sotoodehnia N, Stott DJ, Stürmer T, Taylor KD, Thornton TA, Uitterlinden AG, Wilhelmsen KC, Wilson JG, Gudnason V, Jukema JW, Laurie CC, Liu Y, Mook-Kanamori DO, Munroe PB, Rotter JI, Vasan RS, Psaty BM, Stricker BH, Whitsel EA.
J Med Genet. 2016 Dec 30. pii: jmedgenet-2016-104112. doi: 10.1136/jmedgenet-2016-104112. [Epub ahead of print] PMID: 28039329

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype.

Direk N, Williams S, Smith JA, Ripke S, Air T, Amare AT, Amin N, Baune BT, Bennett DA, Blackwood DH, Boomsma D, Breen G, Buttenschøn HN, Byrne EM, Børglum AD, Castelao E, Cichon S, Clarke TK, Cornelis MC, Dannlowski U, De Jager PL, Demirkan A, Domenici E, van Duijn CM, Dunn EC, Eriksson JG, Esko T, Faul JD, Ferrucci L, Fornage M, de Geus E, Gill M, Gordon SD, Grabe HJ, van Grootheest G, Hamilton SP, Hartman CA, Heath AC, Hek K, Hofman A, Homuth G, Horn C, Jan Hottenga J, Kardia SL, Kloiber S, Koenen K, Kutalik Z, Ladwig KH, Lahti J, Levinson DF, Lewis CM, Lewis G, Li QS, Llewellyn DJ, Lucae S, Lunetta KL, MacIntyre DJ, Madden P, Martin NG, McIntosh AM, Metspalu A, Milaneschi Y, Montgomery GW, Mors O, Mosley TH Jr, Murabito JM, Müller-Myhsok B, Nöthen MM, Nyholt DR, O’Donovan MC, Penninx BW, Pergadia ML, Perlis R, Potash JB, Preisig M, Purcell SM, Quiroz JA, Räikkönen K, Rice JP, Rietschel M, Rivera M, Schulze TG, Shi J, Shyn S, Sinnamon GC, Smit JH, Smoller JW, Snieder H, Tanaka T, Tansey KE, Teumer A, Uher R, Umbricht D, Van der Auwera S, Ware EB, Weir DR, Weissman MM, Willemsen G, Yang J, Zhao W, Tiemeier H, Sullivan PF.
Biol Psychiatry. 2016 Dec 8. pii: S0006-3223(16)33068-2. doi: 10.1016/j.biopsych.2016.11.013. [Epub ahead of print] PMID: 28049566

Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body.

Duronio RJ, Marzluff WF.
RNA Biol. 2017 Jan 6:0. doi: 10.1080/15476286.2016.1265198. [Epub ahead of print] PMID: 28059623

Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3′ variants.

Yamane D, Selitsky SR, Shimakami T, Li Y, Zhou M, Honda M, Sethupathy P, Lemon SM.
Nucleic Acids Res. 2017 Jan 12. pii: gkw1332. doi: 10.1093/nar/gkw1332. [Epub ahead of print] PMID: 28082397

Genome sequencing and carrier testing: decisions on categorization and whether to disclose results of carrier testing.

Himes P, Kauffman TL, Muessig KR, Amendola LM, Berg JS, Dorschner MO, Gilmore M, Nickerson DA, Reiss JA, Richards CS, Rope AF, Simpson DK, Wilfond BS, Jarvik GP, Goddard KA.
Genet Med. 2017 Jan 12. doi: 10.1038/gim.2016.198. [Epub ahead of print] PMID: 28079899

ClinGen Pathogenicity Calculator: a configurable system for assessing pathogenicity of genetic variants.

Patel RY, Shah N, Jackson AR, Ghosh R, Pawliczek P, Paithankar S, Baker A, Riehle K, Chen H, Milosavljevic S, Bizon C, Rynearson S, Nelson T, Jarvik GP, Rehm HL, Harrison SM, Azzariti D, Powell B, Babb L, Plon SE, Milosavljevic A;
ClinGen Resource.. Genome Med. 2017 Jan 12;9(1):3. doi: 10.1186/s13073-016-0391-z.
PMID: 28081714

Statistical significance for hierarchical clustering.

Kimes PK, Liu Y, Neil Hayes D, Marron JS.
Biometrics. 2017 Jan 18. doi: 10.1111/biom.12647. [Epub ahead of print] PMID: 28099990

Newborn Sequencing in Genomic Medicine and Public Health.

Berg JS, Agrawal PB, Bailey DB Jr, Beggs AH, Brenner SE, Brower AM, Cakici JA, Ceyhan-Birsoy O, Chan K, Chen F, Currier RJ, Dukhovny D, Green RC, Harris-Wai J, Holm IA, Iglesias B, Joseph G, Kingsmore SF, Koenig BA, Kwok PY, Lantos J, Leeder SJ, Lewis MA, McGuire AL, Milko LV, Mooney SD, Parad RB, Pereira S, Petrikin J, Powell BC, Powell CM, Puck JM, Rehm HL, Risch N, Roche M, Shieh JT, Veeraraghavan N, Watson MS, Willig L, Yu TW, Urv T, Wise AL.
Pediatrics. 2017 Jan 17. pii: e20162252. doi: 10.1542/peds.2016-2252. [Epub ahead of print] PMID: 28096516

Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust microRNA Sensitivity in Intestinal Stem Cells to Microbial Status.

Peck BC, Mah AT, Pitman WA, Ding S, Lund PK, Sethupathy P. J
Biol Chem. 2017 Jan 4. pii: jbc.M116.770099. doi: 10.1074/jbc.M116.770099. [Epub ahead of print] PMID: 28053090