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Department of Genetics faculty and collaborators published twelve papers between August 6 and August 19, 2017.

Upregulation of autophagy genes and the unfolded protein response in human heart failure.

Jensen BC, Bultman SJ, Holley D, Tang W, de Ridder G, Pizzo S, Bowles D, Willis MS.

Int J Clin Exp Med. 2017;10(1):1051-1058. Epub 2017 Jan 30.

PMID: 28794819

Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity.

Guo J, Otis JM, Higginbotham H, Monckton C, Cheng J, Asokan A, Mykytyn K, Caspary T, Stuber GD, Anton ES.

Dev Cell. 2017 Aug 7;42(3):286-300.e4. doi: 10.1016/j.devcel.2017.07.010.

PMID: 28787594

Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia.

Genovese G, Fromer M, Stahl EA, Ruderfer DM, Chambert K, Landén M, Moran JL, Purcell SM, Sklar P, Sullivan PF, Hultman CM, McCarroll SA.

Nat Neurosci. 2016 Nov;19(11):1433-1441. doi: 10.1038/nn.4402. Epub 2016 Oct 3.

PMID: 27694994

LAG-3 Confers a Competitive Disadvantage upon Antiviral CD8+ T Cell Responses.

Cook KD, Whitmire JK.

J Immunol. 2016 Jul 1;197(1):119-27. doi: 10.4049/jimmunol.1401594. Epub 2016 May 20.

PMID: 27206765

Associations between Genomic Variants in Alcohol Dehydrogenase (ADH) Genes and Alcohol Symptomatology in American Indians and European Americans: Distinctions and Convergence.

Peng Q, Gizer IR, Wilhelmsen KC, Ehlers CL.

Alcohol Clin Exp Res. 2017 Aug 16. doi: 10.1111/acer.13480. [Epub ahead of print]

PMID: 28815635

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.

Robertson AG, Shih J, Yau C, Gibb EA, Oba J, Mungall KL, Hess JM, Uzunangelov V, Walter V, Danilova L, Lichtenberg TM, Kucherlapati M, Kimes PK, Tang M, Penson A, Babur O, Akbani R, Bristow CA, Hoadley KA, Iype L, Chang MT; TCGA Research Network, Cherniack AD, Benz C, Mills GB, Verhaak RGW, Griewank KG, Felau I, Zenklusen JC, Gershenwald JE, Schoenfield L, Lazar AJ, Abdel-Rahman MH, Roman-Roman S, Stern MH, Cebulla CM, Williams MD, Jager MJ, Coupland SE, Esmaeli B, Kandoth C, Woodman SE.

Cancer Cell. 2017 Aug 14;32(2):204-220.e15. doi: 10.1016/j.ccell.2017.07.003.

PMID: 28810145

An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.

Souroullas GP, Jeck WR, Parker JS, Simon JM, Liu JY, Paulk J, Xiong J, Clark KS, Fedoriw Y, Qi J, Burd CE, Bradner JE, Sharpless NE.

Nat Med. 2016 Jun;22(6):632-40. doi: 10.1038/nm.4092. Epub 2016 May 2.

PMID: 27135738

Prospective assessment of serum periostin as a biomarker for diagnosis and monitoring of eosinophilic oesophagitis.

Dellon ES, Higgins LL, Beitia R, Rusin S, Woosley JT, Veerappan R, Selitsky SR, Parker JS, Genta RM, Lash RH, Aranda R, Peach RJ, Grimm M.

Aliment Pharmacol Ther. 2016 Jul;44(2):189-97. doi: 10.1111/apt.13672. Epub 2016 May 18.

PMID: 27193351

Bloom syndrome helicase in meiosis: Pro-crossover functions of an anti-crossover protein.

Hatkevich T, Sekelsky J.

Bioessays. 2017 Aug 9. doi: 10.1002/bies.201700073. [Epub ahead of print] Review.

PMID: 28792069

Bone health and SATB2-associated syndrome.

Zarate YA, Steinraths M, Matthews A, Smith W, Sun A, Wilson LC, Brain C, Allgove J, Jacobs B, Fish JL, Powell CM, Wasserman W, Van Karnebeek C, Wakeling EL, Ma NS.

Clin Genet. 2017 Aug 8. doi: 10.1111/cge.13121. [Epub ahead of print]

PMID: 28787087

Population Pharmacokinetics Modeling of Unbound Efavirenz, Atazanavir, and Ritonavir in HIV-Infected Subjects With Aging Biomarkers.

Dumond JB, Chen J, Cottrell M, Trezza CR, Prince H, Sykes C, Torrice C, White N, Malone S, Wang R, Patterson KB, Sharpless NE, Forrest A.

CPT Pharmacometrics Syst Pharmacol. 2017 Feb;6(2):128-135. doi: 10.1002/psp4.12151. Epub 2016 Dec 29.

PMID: 28032946

Fragile X Newborn Screening: Lessons Learned From a Multisite Screening Study.

Bailey DB Jr, Berry-Kravis E, Gane LW, Guarda S, Hagerman R, Powell CM, Tassone F, Wheeler A.

Pediatrics. 2017 Jun;139(Suppl 3):S216-S225. doi: 10.1542/peds.2016-1159H.

PMID: 28814542