Department of Genetics Publications for Feb. 25 – March 10, 2018

Department of Genetics faculty, postdocs, students and collaborators published eleven papers during Feb. 25 – March 10, 2018.

Identification of seven novel loci associated with amino acid levels using single variant and gene-based tests in 8,545 Finnish men from the METSIM study.

Teslovich TM, Kim DS, Yin X, Stancáková A, Jackson AU, Wielscher M, Naj A, Perry JRB, Huyghe JR, Stringham HM, Davis JP, Raulerson CK, Welch RP, Fuchsberger C, Locke AE, Sim X, Chines PS, Narisu N, Kangas AJ, Soininen P; Genetics of Obesity-related Liver Disease Consortium (GOLD), The Alzheimer’s Disease Genetics Consortium (ADGC), The DIAbetes Genetics Replication And Meta-analysis (DIAGRAM), Ala-Korpela M, Gudnason V, Musani SK, Jarvelin MR, Schellenberg GD, Speliotes EK, Kuusisto J, Collins FS, Boehnke M, Laakso M, Mohlke KL.

Hum Mol Genet. 2018 Feb 21. doi: 10.1093/hmg/ddy067. [Epub ahead of print]

PMID: 29481666

Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer.

Siegel MB, He X, Hoadley KA, Hoyle A, Pearce JB, Garrett AL, Kumar S, Moylan VJ, Brady CM, Van Swearingen AE, Marron D, Gupta GP, Thorne LB, Kieran N, Livasy C, Mardis ER, Parker JS, Chen M, Anders CK, Carey LA,Perou CM.

J Clin Invest. 2018 Feb 26. pii: 96153. doi: 10.1172/JCI96153. [Epub ahead of print]

PMID: 29480819

An Adeno-Associated Virus-Based Toolkit for Preferential Targeting and Manipulating Quiescent Neural Stem Cells in the Adult Hippocampus.

Crowther AJ, Lim SA, Asrican B, Albright BH, Wooten J, Yeh CY, Bao H, Cerri DH, Hu J, Ian Shih YY, Asokan A, Song J.

Stem Cell Reports. 2018 Feb 17. pii: S2213-6711(18)30044-4. doi: 10.1016/j.stemcr.2018.01.018. [Epub ahead of print]

PMID: 29478897

The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice.

Manvich DF, Webster KA, Foster SL, Farrell MS, Ritchie JC, Porter JH, Weinshenker D.

Sci Rep. 2018 Mar 1;8(1):3840. doi: 10.1038/s41598-018-22116-z.

PMID: 29497149

A randomized approach to speed up the analysis of large-scale read-count data in the application of CNV detection.

Wang W, Sun W, Wang W, Szatkiewicz J.

BMC Bioinformatics. 2018 Mar 1;19(1):74. doi: 10.1186/s12859-018-2077-6.

PMID: 29490610

Observation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications.

Van den Berge K, Perraudeau F, Soneson C, Love MI, Risso D, Vert JP, Robinson MD, Dudoit S, Clement L.

Genome Biol. 2018 Feb 26;19(1):24. doi: 10.1186/s13059-018-1406-4.

PMID: 29478411

Immuno-PET imaging of tumor-infiltrating lymphocytes using zirconium-89 radiolabeled anti-CD3 antibody in immune-competent mice bearing syngeneic tumors.

Beckford Vera DR, Smith CC, Bixby LM, Glatt DM, Dunn SS, Saito R, Kim WY, Serody JS, Vincent BG, Parrott MC.

PLoS One. 2018 Mar 7;13(3):e0193832. doi: 10.1371/journal.pone.0193832. eCollection 2018.

PMID: 29513764

Developmental constraint through negative pleiotropy in the zygomatic arch.

Percival CJ, Green R, Roseman CC, Gatti DM, Morgan JL, Murray SA, Donahue LR, Mayeux JM, Pollard KM, Hua K, Pomp D, Marcucio R, Hallgrímsson B.

Evodevo. 2018 Jan 27;9:3. doi: 10.1186/s13227-018-0092-3. eCollection 2018.

PMID: 29423138

A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia.

Sakamoto K, Crowley JJ.

Am J Med Genet B Neuropsychiatr Genet. 2018 Mar;177(2):242-256. doi: 10.1002/ajmg.b.32554. Epub 2017 Jun 14. Review.

PMID:  29442441

Ceratocystis cacaofunesta genome analysis reveals a large expansion of extracellular phosphatidylinositol-specific phospholipase-C genes (PI-PLC).

Molano EPL, Cabrera OG, Jose J, do Nascimento LC, Carazzolle MF, Teixeira PJPL, Alvarez JC, Tiburcio RA, Tokimatu Filho PM, de Lima GMA, Guido RVC, Corrêa TLR, Leme AFP, Mieczkowski P, Pereira GAG.

BMC Genomics. 2018 Jan 17;19(1):58. doi: 10.1186/s12864-018-4440-4.

PMID: 29343217

Whole Genome Sequence Analysis of Mutations Accumulated in rad27Δ Yeast Strains with Defects in the Processing of Okazaki Fragments Indicates Template-Switching Events.

Omer S, Lavi B, Mieczkowski PA, Covo S, Hazkani-Covo E.

G3 (Bethesda). 2017 Nov 6;7(11):3775-3787. doi: 10.1534/g3.117.300262.

PMID:  28974572