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UNC Genetics PublicationsDepartment of Genetics faculty, postdocs, students and collaborators published 8 papers during March 12th – 25th, 2023.

Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. 

Liu D, Meyer D, Fennessy B, Feng C, Cheng E, Johnson JS, Park YJ, Rieder MK, Ascolillo S, de Pins A, Dobbyn A, Lebovitch D, Moya E, Nguyen TH, Wilkins L, Hassan A; Psychiatric Genomics Consortium Phase 3 Targeted Sequencing of Schizophrenia Study Team; Burdick KE, Buxbaum JD, Domenici E, Frangou S, Hartmann AM, Laurent-Levinson C, Malhotra D, Pato CN, Pato MT, Ressler K, Roussos P, Rujescu D, Arango C, Bertolino A, Blasi G, Bocchio-Chiavetto L, Campion D, Carr V, Fullerton JM, Gennarelli M, González-Peñas J, Levinson DF, Mowry B, Nimgaokar VL, Pergola G, Rampino A, Cervilla JA, Rivera M, Schwab SG, Wildenauer DB, Daly M, Neale B, Singh T, O’Donovan MC, Owen MJ, Walters JT, Ayub M, Malhotra AK, Lencz T, Sullivan PF, Sklar P, Stahl EA, Huckins LM, Charney AW.

Nat Genet. 2023 Mar;55(3):369-376. doi: 10.1038/s41588-023-01305-1. Epub 2023 Mar 13.

PMID: 36914870 Free PMC article.

 

Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds. 

Swift SK, Purdy AL, Kolell ME, Andresen KG, Lahue C, Buddell T, Akins KA, Rau CD, O’Meara CC, Patterson M.

Development. 2023 Mar 13:dev.201318. doi: 10.1242/dev.201318. Online ahead of print.

PMID: 36912240

 

SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers. 

Shi L, Shen W, Davis MI, Kong K, Vu P, Saha SK, Adil R, Kreuzer J, Egan R, Lee TD, Greninger P, Shrimp JH, Zhao W, Wei TY, Zhou M, Eccleston J, Sussman J, Manocha U, Weerasekara V, Kondo H, Vijay V, Wu MJ, Kearney SE, Ho J, McClanaghan J, Murchie E, Crowther GS, Patnaik S, Boxer MB, Shen M, Ting DT, Kim WY, Stanger BZ, Deshpande V, Ferrone CR, Benes CH, Haas W, Hall MD, Bardeesy N.

Nat Cancer. 2023 Mar 13. doi: 10.1038/s43018-023-00523-0. Online ahead of print.

PMID: 36914816

 

CpG methylation levels in HPA axis genes predict chronic pain outcomes following trauma exposure. 

Branham EM, McLean SA, Deliwala I, Mauck MC, Zhao Y, McKibben LA, Lee A, Spencer AB, Zannas AS, Lechner M, Danza T, Velilla MA, Hendry PL, Pearson C, Peak DA, Jones J, Rathlev NK, Linnstaedt SD.

J Pain. 2023 Mar 9:S1526-5900(23)00364-4. doi: 10.1016/j.jpain.2023.03.001. Online ahead of print.

PMID: 36906051

 

Editorial: Epigenetic regulation in cardiovascular diseases, volume II. 

Xu S, Pillai ICL, Rau CD, Wang Z.

Front Cardiovasc Med. 2023 Mar 6;10:1166268. doi: 10.3389/fcvm.2023.1166268. eCollection 2023.

PMID: 36950284 Free PMC article. No abstract available.

 

Localizing post-admixture adaptive variants with object detection on ancestry-painted chromosomes. 

Hamid I, Korunes KL, Schrider DR, Goldberg A.

Mol Biol Evol. 2023 Mar 22:msad074. doi: 10.1093/molbev/msad074. Online ahead of print.

PMID: 36947126

 

Epigenetic aging and PTSD outcomes in the immediate aftermath of trauma. 

Zannas AS, Linnstaedt SD, An X, Stevens JS, Harnett NG, Roeckner AR, Oliver KI, Rubinow DR, Binder EB, Koenen KC, Ressler KJ, McLean SA.

Psychol Med. 2023 Mar 23:1-10. doi: 10.1017/S0033291723000636. Online ahead of print.

PMID: 36951141

 

Plastid Genome Assembly Using Long-read Data (ptGAUL). 

Zhou W, Armijos CE, Lee C, Lu R, Wang J, Ruhlman TA, Jansen RK, Jones AM, Jones CD.

Mol Ecol Resour. 2023 Mar 20. doi: 10.1111/1755-0998.13787. Online ahead of print.

PMID: 36939021