Department of Genetics faculty, postdocs, students and collaborators published eleven papers during November 18 – December 1, 2018

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Enhancer deletion and allelic effects define a regulatory molecular mechanism at the VLDLR cholesterol GWAS locus.

Davis JP, Vadlamudi S, Roman TS, Zeynalzadeh M, Iyengar AK, Mohlke KL.

Hum Mol Genet. 2018 Nov 16. doi: 10.1093/hmg/ddy385. [Epub ahead of print]

PMID: 30445632

PPD ACT: an app-based genetic study of postpartum depression.

Guintivano J, Krohn H, Lewis C, Byrne EM, Henders AK, Ploner A, Kirk K, Martin NG, Milgrom J, Wray NR, Sullivan PF, Meltzer-Brody S.

Transl Psychiatry. 2018 Nov 29;8(1):260. doi: 10.1038/s41398-018-0305-5.

PMID: 30498212

Identification of Jun loss promotes resistance to histone deacetylase inhibitor entinostat through Myc signaling in luminal breast cancer.

Tanioka M, Mott KR, Hollern DP, Fan C, Darr DB, Perou CM.

Genome Med. 2018 Nov 30;10(1):86. doi: 10.1186/s13073-018-0597-3.

PMID: 30497520

Unveiling the regulation of NKT17 cell differentiation and function.

Tsagaratou A.

Mol Immunol. 2018 Nov 26;105:55-61. doi: 10.1016/j.molimm.2018.11.013. [Epub ahead of print]

PMID: 30496977

Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

Takeuchi F, Akiyama M, Matoba N, Katsuya T, Nakatochi M, Tabara Y, Narita A, Saw WY, Moon S, Spracklen CN, Chai JF, Kim YJ, Zhang L, Wang C, Li H, Li H, Wu JY, Dorajoo R, Nierenberg JL, Wang YX, He J, Bennett DA, Takahashi A, Momozawa Y, Hirata M, Matsuda K, Rakugi H, Nakashima E, Isono M, Shirota M, Hozawa A, Ichihara S, Matsubara T, Yamamoto K, Kohara K, Igase M, Han S, Gordon-Larsen P, Huang W, Lee NR, Adair LS, Hwang MY, Lee J, Chee ML, Sabanayagam C, Zhao W, Liu J, Reilly DF, Sun L, Huo S, Edwards TL, Long J, Chang LC, Chen CH, Yuan JM, Koh WP, Friedlander Y, Kelly TN, Bin Wei W, Xu L, Cai H, Xiang YB, Lin K, Clarke R, Walters RG, Millwood IY, Li L, Chambers JC, Kooner JS, Elliott P, van der Harst P; International Genomics of Blood Pressure (iGEN-BP) Consortium, Chen Z, Sasaki M, Shu XO, Jonas JB, He J, Heng CK, Chen YT, Zheng W, Lin X, Teo YY, Tai ES, Cheng CY, Wong TY, Sim X, Mohlke KL, Yamamoto M, Kim BJ, Miki T, Nabika T, Yokota M, Kamatani Y, Kubo M, Kato N.

Nat Commun. 2018 Nov 28;9(1):5052. doi: 10.1038/s41467-018-07345-0.

PMID: 30487518

A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer.

Hollern DP, Contreras CM, Dance-Barnes S, Silva GO, Pfefferle AD, Xiong J, Darr DB, Usary J, Mott KR, Perou CM.

Breast Cancer Res Treat. 2018 Nov 27. doi: 10.1007/s10549-018-5061-y. [Epub ahead of print]

PMID: 30484104

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.

Demontis D, Walters RK, Martin J, Mattheisen M, Als TD, Agerbo E, Baldursson G, Belliveau R, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Churchhouse C, Dumont A, Eriksson N, Gandal M, Goldstein JI, Grasby KL, Grove J, Gudmundsson OO, Hansen CS, Hauberg ME, Hollegaard MV, Howrigan DP, Huang H, Maller JB, Martin AR, Martin NG, Moran J, Pallesen J, Palmer DS, Pedersen CB, Pedersen MG, Poterba T, Poulsen JB, Ripke S, Robinson EB, Satterstrom FK, Stefansson H, Stevens C, Turley P, Walters GB, Won H, Wright MJ; ADHD Working Group of the Psychiatric Genomics Consortium (PGC); Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium; 23andMe Research Team, Andreassen OA, Asherson P, Burton CL, Boomsma DI, Cormand B, Dalsgaard S, Franke B, Gelernter J, Geschwind D, Hakonarson H, Haavik J, Kranzler HR, Kuntsi J, Langley K, Lesch KP, Middeldorp C, Reif A, Rohde LA, Roussos P, Schachar R, Sklar P, Sonuga-Barke EJS, Sullivan PF, Thapar A, Tung JY, Waldman ID, Medland SE, Stefansson K, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Daly MJ, Faraone SV, Børglum AD, Neale BM.

Nat Genet. 2018 Nov 26. doi: 10.1038/s41588-018-0269-7. [Epub ahead of print]

PMID: 30478444

Bacterial butyrate prevents atherosclerosis.

Bultman SJ.

Nat Microbiol. 2018 Dec;3(12):1332-1333. doi: 10.1038/s41564-018-0299-z. No abstract available.

PMID: 30478384

The many fates of tissue regeneration.

Abdullah C, Duronio RJ.

PLoS Genet. 2018 Nov 21;14(11):e1007728. doi: 10.1371/journal.pgen.1007728. eCollection 2018 Nov. No abstract available.

PMID: 30462634

A behavior-theoretic evaluation of values clarification on parental beliefs and intentions toward genomic sequencing for newborns.

Paquin RS, Peinado S, Lewis MA, Biesecker BB, Rini C, Roche M, Butterfield RM, Powell CM, Berg JS, Bailey DB Jr.

Soc Sci Med. 2018 Nov 9. pii: S0277-9536(18)30651-8. doi: 10.1016/j.socscimed.2018.11.017. [Epub ahead of print]

PMID: 30448267

CODEX2: full-spectrum copy number variation detection by high-throughput DNA sequencing.

Jiang Y, Wang R, Urrutia E, Anastopoulos IN, Nathanson KL, Zhang NR.

Genome Biol. 2018 Nov 26;19(1):202. doi: 10.1186/s13059-018-1578-y.

PMID: 30477554