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Department of Genetics faculty, postdocs, students and collaborators published twelve papers during Sept. 23 – Oct. 6, 2018.

Investigation of tunable acetalated dextran microparticle platform to optimize M2e-based influenza vaccine efficacy.

Chen N, Gallovic MD, Tiet P, Ting JP, Ainslie KM, Bachelder EM.

J Control Release. 2018 Sep 24. pii: S0168-3659(18)30550-9. doi: 10.1016/j.jconrel.2018.09.020. [Epub ahead of print]

PMID: 30261204

Too much of a good thing? Overdiagnosis, or overestimating risk in preventive genomic screening.

Meagher KM, Berg JS.

Per Med. 2018 Sep 27. doi: 10.2217/pme-2018-0041. [Epub ahead of print] No abstract available.

PMID: 30260288

Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits.

Freund MK, Burch KS, Shi H, Mancuso N, Kichaev G, Garske KM, Pan DZ, Miao Z, Mohlke KL, Laakso M, Pajukanta P, Pasaniuc B, Arboleda VA.

Am J Hum Genet. 2018 Oct 4;103(4):535-552. doi: 10.1016/j.ajhg.2018.08.017.

PMID: 30290150

Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study.

Hart MR, Biesecker BB, Blout CL, Christensen KD, Amendola LM, Bergstrom KL, Biswas S, Bowling KM, Brothers KB, Conlin LK, Cooper GM, Dulik MC, East KM, Everett JN, Finnila CR, Ghazani AA, Gilmore MJ, Goddard KAB, Jarvik GP, Johnston JJ, Kauffman TL, Kelley WV, Krier JB, Lewis KL, McGuire AL, McMullen C, Ou J, Plon SE, Rehm HL, Richards CS, Romasko EJ, Miren Sagardia A, Spinner NB, Thompson ML, Turbitt E, Vassy JL, Wilfond BS, Veenstra DL, Berg JS, Green RC, Biesecker LG, Hindorff LA.

Genet Med. 2018 Oct 5. doi: 10.1038/s41436-018-0308-x. [Epub ahead of print]

PMID: 30287922

The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions.

Wang Y, Song F, Zhang B, Zhang L, Xu J, Kuang D, Li D, Choudhary MNK, Li Y, Hu M, Hardison R, Wang T, Yue F.

Genome Biol. 2018 Oct 4;19(1):151. doi: 10.1186/s13059-018-1519-9.

PMID: 30286773

Colonic epithelial miR-31 associates with the development of Crohn’s phenotypes.

Keith BP, Barrow JB, Toyonaga T, Kazgan N, O’Connor MH, Shah ND, Schaner MS, Wolber EA, Trad OK, Gipson GR, Pitman WA, Kanke M, Saxena SJ, Chaumont N, Sadiq TS, Koruda MJ, Cotney PA, Allbritton N, Trembath DG, Sylvester F, Furey TS, Sethupathy P, Sheikh SZ.

JCI Insight. 2018 Oct 4;3(19). pii: 122788. doi: 10.1172/jci.insight.122788. [Epub ahead of print]

PMID: 30282822

Epstein-Barr Virus-Positive Cancers Show Altered B-Cell Clonality.

Selitsky SR, Marron D, Mose LE, Parker JS, Dittmer DP.

mSystems. 2018 Sep 25;3(5). pii: e00081-18. doi: 10.1128/mSystems.00081-18. eCollection 2018 Sep-Oct.

PMID: 30271878

ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer.

Cai L, Tsai YH, Wang P, Wang J, Li D, Fan H, Zhao Y, Bareja R, Lu R, Wilson EM, Sboner A, Whang YE, Zheng D, Parker JS, Earp HS, Wang GG.

Mol Cell. 2018 Sep 11. pii: S1097-2765(18)30689-0. doi: 10.1016/j.molcel.2018.08.029. [Epub ahead of print]

PMID: 30270106

Male breast cancer: a disease distinct from female breast cancer.

Gucalp A, Traina TA, Eisner JR, Parker JS, Selitsky SR, Park BH, Elias AD, Baskin-Bey ES, Cardoso F.

Breast Cancer Res Treat. 2018 Sep 28. doi: 10.1007/s10549-018-4921-9. [Epub ahead of print] Review.

PMID: 30267249

Why Does the Shift from “Personalized Medicine” to “Precision Health” and “Wellness Genomics” Matter?

Juengst ET, McGowan ML.

AMA J Ethics. 2018 Sep 1;20(9):E881-890. doi: 10.1001/amajethics.2018.881.

PMID: 30242820

Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila.

Armstrong RL, Penke TJR, Strahl BD, Matera AG, McKay DJ, MacAlpine DM, Duronio RJ.

Genome Res. 2018 Oct 2. pii: gr.239913.118. doi: 10.1101/gr.239913.118. [Epub ahead of print]

PMID: 30279224

Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity.

Edwards AC, Deak JD, Gizer IR, Lai D, Chatzinakos C, Wilhelmsen KP, Lindsay J, Heron J, Hickman M, Webb BT, Bacanu SA, Foroud TM, Kendler KS, Dick DM, Schuckit MA; Collaborative Study on the Genetics of Alcoholism (COGA).

Alcohol Clin Exp Res. 2018 Oct 1. doi: 10.1111/acer.13896. [Epub ahead of print]

PMID: 30276832